2,3-Dibromo-5-chloropyridine Chemical Properties

Melting point:

41.0 to 45.0 °C

Boiling point:

259.9±35.0 °C(Predicted)

Density 

2.136±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

-3.85±0.20(Predicted)

color 

White to Light yellow to Light orange

InChI

InChI=1S/C5H2Br2ClN/c6-4-1-3(8)2-9-5(4)7/h1-2H

InChIKey

GDUFWKJMOOVEMX-UHFFFAOYSA-N

SMILES

C1(Br)=NC=C(Cl)C=C1Br

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38-25

Safety Statements 

26-37-45

RIDADR 

UN 2811 6.1 / PGIII

HazardClass 

IRRITANT

HS Code 

2933399990

2,3-Dibromo-5-chloropyridine Usage And Synthesis

Uses

2,3-Dibromo-5-chloropyridine has been used as a reactant for regiospecific Grignard reactions with lactones.

Synthesis

3-Bromo-5-chloropyridone (8.0 g, 38.4 mmole) was dissolved in dimethylformamide (60 ml) at ambient temperature. Phosphorus (V) tribromide oxide (16.5 g, 57.6 mmoles) was added and the reaction heated to 80° C for 72 hours. After cooling, the reaction was poured onto 800 g of ice. Vacuum filtration provided the product as a dark solid (6.85 g). Hexane (225 ml) and decolorizing carbon was added to the crude product and the contents heated to reflux and then filtered through celite. The clear colorless filtrate was stripped under vacuum to yield 2,3-Dibromo-5-chloropyridine as a white solid (5.3 g, 51%).

2,3-Dibromo-5-chloropyridine(137628-17-2)Related Product Information

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