Basic information Safety Supplier Related

Tacalcitol

Basic information Safety Supplier Related

Tacalcitol Basic information

Product Name:
Tacalcitol
Synonyms:
  • (1α,3β-5Z,7E,24R)-9,10-Secoholesta-5,7,10(19)-triene-1,3,24-triol
  • lα,24-Dihydroxycholecalciferol
  • lα,24R-Dihy-droxyvitamin D3
  • [5Z,7E,24R,(+)]-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,24-triol
  • 1α,24(R)-Dihydroxyvitamin D3
  • 1α,24R-Dihydroxyvitamin D3
  • (1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol
  • C12919
CAS:
57333-96-7
MF:
C27H44O3
MW:
416.64
Product Categories:
  • Vitamin D3 analogs
Mol File:
57333-96-7.mol
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Tacalcitol Chemical Properties

Boiling point:
565.0±50.0 °C(Predicted)
Density 
1.06
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
20mg/mL in DMSO, 20mg/mL in DMF, 20mg/mL in Ethanol
pka
14.43±0.40(Predicted)
form 
Powder
color 
White to off-white
CAS DataBase Reference
57333-96-7(CAS DataBase Reference)
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Tacalcitol Usage And Synthesis

Description

Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar pustulosis and keratoderma. It shows improvement in appearance of skin lesions for psoriasis patients without significant side effects. In patients with psoriasis vulgaris, it effectively inhibits keratinocyte growth. Some in vitro studies have shown that tacalcitol inhibits interleukin-1-α-induced granulocyte macrophage colony-stimulating-factor mRNA expression of the human dermal microvascular endothelial cells, which may be involved in mediation of angioproliferation in skin inflammation.

Originator

Teijin (Japan)

Uses

Tacalcitol is a synthetic vitamin D3 analog.

Definition

ChEBI: Tacalcitol is a hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp. It has a role as an antipsoriatic, a vitamin D receptor agonist and an antineoplastic agent. It is a member of D3 vitamins, a hydroxy seco-steroid, a secondary alcohol and a seco-cholestane. It is functionally related to a calciol.

brand name

Bonalfa

Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors,

TacalcitolSupplier

Chemvon Biotechnology Co., Ltd Gold
Tel
021-50790412
Email
info@chemvon.com
Shanghai Boyle Chemical Co., Ltd.
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Email
sales@boylechem.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Chembest Research Laboratories Limited
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+86-21-20908456
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sales@BioChemBest.com
Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
Email
sales@capotchem.com
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