(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Chemical Properties

Melting point:

136-142 °C

Boiling point:

491.8±45.0 °C(Predicted)

Density 

1.256±0.06 g/cm3(Predicted)

pka

3.82±0.50(Predicted)

CAS DataBase Reference

148901-68-2(CAS DataBase Reference)

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal Usage And Synthesis

Synthesis

The general procedure for the synthesis of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]acrolein from the compound (CAS: 113832-57-8) and 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde is as follows: the general procedure is as follows: except for the use of ethylidene cyclohexylamine (1.7 g, 13.8 mmol) in place of the ethylidene tert-butylamine (1.4 g, 14.1 mmol), the operation was the same as in Example 1. A portion of the reaction mixture was poured into 10% (w/v) aqueous acetic acid solution and analyzed by high performance liquid chromatography (HPLC) using the internal standard method. The analytical results showed that (E)-3-[4'-(4"-fluorophenyl)-2'-cyclopropylquinolin-3'-yl]propanal (1.7 g, 5.4 mmol, 78.3% yield) was successfully synthesized.

References

[1] Patent: EP1614682, 2006, A1. Location in patent: Page/Page column 6

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal(148901-68-2)Related Product Information

• (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
• 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline
• 2-Amino-4'-fluorobenzophenone
• 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde
• 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol
• 3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER
• Methyl 3-cyclopropyl-3-oxopropionate
• Methyl 4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinecarboxylate
• Ethyl (E)-3,5-dihydroxy-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-hept-6-enoate
• Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate
• Quinclorac
• Ethoxyquin
• Quinhydrone
• Quinolinic acid
• Isoquinoline
• Acrolein
• Pitavastatin
• (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal