Basic information Safety Supplier Related

Ranolazine

Basic information Safety Supplier Related

Ranolazine Basic information

Product Name:
Ranolazine
Synonyms:
  • (Mu7-((diosmin heptasulfato)(7-)))tetracontahydroxytetradecaaluminum
  • Ranolazine USP/EP/BP
CAS:
122312-55-4
MF:
C28H61Al16O79S8
MW:
2349.95
Mol File:
122312-55-4.mol
More
Less

Ranolazine Usage And Synthesis

Description

Dosmalfate, a heptakis(hydrogensulfate) aluminium complex of diosmin, was launched in Spain for the prevention and treatment of gastroduodenal lesions induced by NSAID therapy. Dosmalfate can be prepared from diosmin by initial treatment with a pyridine sulfur trioxide complex followed by sodium hydroxide and finally aluminium hydroxychloride. In several pharmacological models of acute and chronic ulcers, this new cytoprotective agent has demonstrated significant protection against damage to the gastric mucosa or esophagus erosion, hemorrhage or perforation. Several mechanisms of action could be involved, partly mediated by the endogenous prostaglandins. In several clinical studies with patients receiving long-term NSAID therapy for chronic inflammatory disease, the efficacy of dosmalfate in preventing gastric ulcer was high and comparable to that of misoprostol, but with significantly less adverse events. In rats and humans, dosmalfate, administered orally at very high doses, displayed a very poor absorption and consequently, a very low incidence of side effects, particularly on CNS, cardiovascular or respiratory systems.

Originator

Faes (Spain)

brand name

Diotul

RanolazineSupplier

Foshan Nanhai Beisha Pharmaceutical Co., Ltd. Gold
Tel
0757-85616808
Email
bsyrylq@163.net
LGM Pharma
Tel
1-(800)-881-8210
Email
inquiries@lgmpharma.com
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Email
1026@dideu.com
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com