Cynaroside
Cynaroside Basic information
- Product Name:
- Cynaroside
- Synonyms:
-
- LUTEOLIN-7-O-GLUCOSIDE 98+%
- 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(.beta.-D-glucopyranosyloxy)-5-hydroxy-
- luteolin7-o-glucopyranoside
- luteoloside
- CYNAROSIDE
- LUTEOLIN-7-GLUCOSIDE
- LUTEOLIN-7-O-GLUCOSIDE
- LUTEOLIN-7-O-GLUCOSIDE WITH HPLC
- CAS:
- 5373-11-5
- MF:
- C21H20O11
- MW:
- 448.38
- EINECS:
- 226-365-8
- Product Categories:
-
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- Cofactor
- Tetra-substituted Flavones
- Mol File:
- 5373-11-5.mol
Cynaroside Chemical Properties
- Melting point:
- 256~258℃
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- Boiling point:
- 838.1±65.0 °C(Predicted)
- Density
- 1.713±0.06 g/cm3(Predicted)
- pka
- 6.10±0.40(Predicted)
- color
- Yellow to Very Dark Yellow
- Stability:
- Hygroscopic
- InChIKey
- PEFNSGRTCBGNAN-QNDFHXLGSA-N
- LogP
- -0.090 (est)
- CAS DataBase Reference
- 5373-11-5(CAS DataBase Reference)
Cynaroside Usage And Synthesis
Effects
Luteolin has a strong bactericidal effect on the respiratory tract, and it is the main active ingredient in the treatment of bronchitis in Qinglan, a unique medicinal material in Xinjiang. Lowers the role of cholesterol in atherosclerosis and enhances capillary relaxation.
Description
Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .
Chemical Properties
Off-white powder
Uses
Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.
Definition
ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
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Cynaroside(5373-11-5)Related Product Information
- Luteolin
- CHLOROPHOSPHONAZO III
- BETA-GLUCOSIDASE
- AMYLOGLUCOSIDASE
- Taxifolin
- luteolin-7-glucuronide
- Luteolin-3'-D-glucuronide
- alkyl polyglucoside
- Ranolazine
- PETUNIDIN CHLORIDE
- Diosmin
- petunidin-3-O-glu,PETUNIDIN3-O-GLUCOSIDE
- ALPHA-BOSWELLIC ACID
- QUERCETIN-7-O-GLUCOSIDE
- LUTEOLIN-7,3'-DI-O-DIGLUCURONIDE
- nepitrin
- OCTYL GLUCOSIDE
- linariifolioside