Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Basic information
- Product Name:
- Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
- Synonyms:
-
- Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)
- Furo[2,3-b]pyridine-2-carboxylicacid,3-amino-, ethyl ester
- ethyl 3-amino furo[2,3-b]pyridine-2-carboxylate
- 3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl ester
- 3-Amino-furo[2,3-b]pyridine-2-carboxylic acid ethyl este
- 2-amino-3-furo[2,3-b]pyridinecarboxylic acid ethyl ester
- 3-aminofuro[2,3-b]pyridine-2-carboxylate
- Ethyl 3-aminofuro[2,3-B]pyridine-2-carboxylate ,98%
- CAS:
- 371945-06-1
- MF:
- C10H10N2O3
- MW:
- 206.2
- Product Categories:
-
- AMINOACID
- Heterocycle-Pyridine series
- Mol File:
- 371945-06-1.mol
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Chemical Properties
- Melting point:
- 134 °C
- Boiling point:
- 342.0±37.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.22±0.40(Predicted)
- Appearance
- White to off-white Solid
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Usage And Synthesis
Synthesis
6602-54-6
623-50-7
371945-06-1
Using 2-chloro-3-cyanopyridine (2.00 g, 1.0 eq.) and ethyl ethanoate (1.43 mL, 1.05 eq.) as raw materials, CuI (0.05 g, 0.02 eq.) and Cs2CO3 (10.3 g, 2.2 eq.) were added to the reaction mixture under stirring conditions. The reaction system was heated to 70°C and maintained at this temperature for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into deionized water (300 mL), and allowed to stand for 1 hour to promote precipitate formation. Subsequently, the precipitate was collected by filtration, ground with a solvent mixture of ether/hexane (1:1, v/v), and finally dried by azeotropic drying with toluene to afford the target product ethyl 3-amino-furo[2,3-b]pyridine-2-carboxylate (51c, 2.0 g, 70% yield).
References
[1] Patent: US2010/261714, 2010, A1. Location in patent: Page/Page column 75
[2] Synthesis, 2007, # 20, p. 3247 - 3251
[3] Patent: WO2017/90058, 2017, A1. Location in patent: Page/Page column 14
[4] Patent: WO2011/21038, 2011, A1. Location in patent: Page/Page column 18; 24
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 2, p. 138 - 142
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)Supplier
- Tel
- +86 (0) 571 85 58 67 18
- Tel
- 001-857-928-2050 or 1-888-588-9418
- sales@chemreagents.com
- Tel
- +86 (21) 6435-5022
- Tel
- 86-531-88280989
- mymail1996@126.com
- Tel
- 18652989687
- sales@norris-pharm.com
Furo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester (9CI)(371945-06-1)Related Product Information
- ETHYL 3-AMINO-4-(TRIFLUOROMETHYL)-6-PHENYLFURO[2,3-B]PYRIDINE-2-CARBOXYLATE
- BUTTPARK 132\40-62
- ETHYL 3-AMINO-4-METHYL-6-PHENYLFURO[2,3-B]PYRIDINE-2-CARBOXYLATE
- BUTTPARK 114\40-43
- BUTTPARK 125\40-41
- ETHYL 3-AMINO-4-(TRIFLUOROMETHYL)-6-P-TOLYLFURO[2,3-B]PYRIDINE-2-CARBOXYLATE
- BUTTPARK 132\40-61
- BUTTPARK 133\40-98
- BUTTPARK 132\40-63
- BUTTPARK 125\40-42
- BUTTPARK 132\40-54
- BUTTPARK 104\40-11
- BUTTPARK 125\40-47
- BUTTPARK 54\40-91
- BUTTPARK 132\40-60
- BUTTPARK 125\40-45
- BUTTPARK 132\40-64
- ETHYL 3-AMINO-6-(4-CHLOROPHENYL)-4-(TRIFLUOROMETHYL)FURO[2,3-B]PYRIDINE-2-CARBOXYLATE