3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester Chemical Properties

Boiling point:

701.6±60.0 °C(Predicted)

Density 

1.385±0.06 g/cm3(Predicted)

pka

3.14±0.10(Predicted)

3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester Usage And Synthesis

Description

ZINC08438472 is a selective agonist of peroxisome proliferator activated receptors-α (PPAR-α).

Uses

ZINC08438472 is a potent and selective peroxisome proliferator activated receptors-α (PPAR-α) agonist with an EC50 value of 12.1 nM. ZINC08438472 is promising for research of diabetes, hyperlipidaemia and inflammatory disorders[1].

References

[1] Gangwal RP, et al. Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-α (PPAR-α) agonists. Bioorg Med Chem Lett. 2015 Jan 15;25(2):270-5. DOI:10.1016/j.bmcl.2014.11.052

3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester(443872-20-6)Related Product Information

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