6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol Chemical Properties

Density 

1.40±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 25mg/mL, clear

pka

7.32±0.20(Predicted)

form 

powder

color 

white to beige

6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol Usage And Synthesis

Description

ZINC05626394 is a Cytochrome b5 reductase 3 (CYB5R3) inhibitor. It acts by increasing NO bioavailability.

Uses

ZINC05626394 is a cytochrome b5 reductase 3 inhibitor with activity by increasing nitric oxide bioavailability. ZINC05626394 may have potential applications in anti-cancer suppression, especially in combination with antibody drug conjugates (ADCs) and immune checkpoint inhibitors. The efficacy of ZINC05626394 may be limited by different mechanisms, including antigen-related resistance and failure of endocytosis[1].

References

[1] Mechanisms of Resistance to Antibody-Drug Conjugates DOI:10.1074/jbc.M114.629964

6-[(phenylsulfanyl)methyl]-2-sulfanylpyrimidin-4-ol(189057-68-9)Related Product Information

• ZINC13466751
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• N-(2-(1H-indol-3-yl)ethyl)-2-((8-oxo-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-12-yl)oxy)propanamide
• 3-Thiophenecarboxylic acid, 5-[[4-(carboxymethoxy)-3-methoxyphenyl]methylene]-2-[(4-ethoxyphenyl)amino]-4,5-dihydro-4-oxo-, 3-ethyl ester
• (5Z)-2-hydroxy-4-methyl-6-oxo-5-[(5-phenylfuran-2-yl)methylidene]-5,6-dihydropyridine-3-carbonitrile
• Benzamide, 4-[2-[1,5-dihydro-1-(4-nitrophenyl)-5-oxo-3-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-
• N-(2-(1H-indol-3-yl)ethyl)-2-((8-oxo-8H-benzo[c]indolo[3,2,1-ij][1,5]naphthyridin-12-yl)oxy)acetamide
• ZINC03129319