Flosulide
Flosulide Basic information
- Product Name:
- Flosulide
- Synonyms:
-
- CGP-28238
- CGP-28328
- N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide
- Flosulide
- N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide
- ZK-38997
- Methanesulfonamide, N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]-
- CAS:
- 80937-31-1
- MF:
- C16H13F2NO4S
- MW:
- 353.344
- Mol File:
- 80937-31-1.mol
Flosulide Chemical Properties
- Melting point:
- 156 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 446.9±55.0 °C(Predicted)
- Density
- 1.506±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 6.95±0.20(Predicted)
Flosulide Usage And Synthesis
Uses
Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
in vivo
In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3].
IC 50
COX-2
References
[1] Turull A, et al. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. Inflammation. 2001 Apr;25(2):119-28. DOI:10.1023/a:1007122706770
[2] Zimmermann KC, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59(1):198-204. PMID:9892207
[3] Heise G, et al. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis. Nephron. 1998 Oct;80(2):220-6. DOI:10.1159/000045171
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Flosulide(80937-31-1)Related Product Information
- 5-Aminoindan
- 6-Methoxy-1H-indanone
- 1-(3-phenoxyphenyl)ethanone
- Flosulide
- 5-INDANOL
- 6-Hydroxy-1-indanone
- 2-(2-FLUOROPHENOXY)ANILINE
- 5-Aminoindan-1-one
- M-(4-FLUOROPHENOXY)TOLUENE
- 3-(4-FLUOROPHENOXY)BENZALDEHYDE
- 2-AMINO-4,5-DIMETHYL-PHENOL
- Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI)
- N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE
- Benzaldehyde, 4-amino-3-methoxy- (9CI)
- 1-(4-AMINO-3-METHOXYPHENYL)-1-ETHANONE
- FK-3311
- (2-PHENOXY)METHYLSULFONYLANILINE
- M-(2-FLUOROPHENOXY)TOLUENE