2-Chloro-5-chloromethylthiophene Chemical Properties

Boiling point:

83-85 °C8 mm Hg(lit.)

Density 

1.385 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.575(lit.)

Flash point:

213 °F

storage temp. 

-20°C

form 

Liquid

color 

Colorless to brown

CAS DataBase Reference

23784-96-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

2-Chloro-5-chloromethylthiophene Usage And Synthesis

Chemical Properties

Clear colorless to yellow liquid

Uses

2-Chloro-5-(chloromethyl)thiophene was used in the synthesis of 1-(1,1′-biphenyl-4-yl)-3-(5-chloro-thiophen-2-yl)-2-(1H-imidazol-1-yl)propane and 1-(5-chlorothiophen-2-yl)-2-(1H-imidazol-1-yl)-3-phenylpropane.

Synthesis

Under nitrogen protection, 5-chloro-2-thiophene methanol (500 mg, 3.37 mmol) was dissolved in tetrahydrofuran (10 mL) and cooled to 0 °C. Subsequently, CN (482 mg, 4.05 mmol) was added dropwise. After the dropwise addition, the reaction mixture was warmed up to 50 °C for 3 h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 480 mg of 2-chloro-5-chloromethylthiophene in yellow liquid form (yield: 85.5%), which could be used directly in the subsequent reaction without further purification.

References

[1] Patent: CN107188865, 2017, A. Location in patent: Paragraph 0113; 0116; 0117

2-Chloro-5-chloromethylthiophene(23784-96-5)Related Product Information

• 2-Chlorothiophene
• Oxalyl chloride
• 2-Chloro-5-chloromethylpyridine
• 2-Chloro-5-chloromethylthiazole
• 2-Chloro-5-methylthiophene
• DIMETHYLTHEXYLSILYL CHLORIDE
• 4-(Chloromethyl)benzoic acid
• Chloromethane
• 2-(Chloromethyl)thiophene
• tert-Butyldimethylsilyl chloride
• Chloromethyl methyl ether
• 2-Chloro-3-chloromethylthiophene
• Difluorochloromethane
• 3,4,5-TRICHLOROTHIOPHENE-2-CARBONYL CHLORIDE
• 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
• 2-Chloro-5-chloromethylthiophene