2-(Trimethylsilyl)thiazole
2-(Trimethylsilyl)thiazole Basic information
- Product Name:
- 2-(Trimethylsilyl)thiazole
- Synonyms:
-
- 2-TST
- 2-THIAZOLYTRIMETHYLSILANE
- 2-Thiazolyltrimethylsilane
- Thiazole, 2-(trimethylsilyl)-
- 2-（trimethyl)thiazole
- 2-TRIMETHYLSILYTHIAZOLE
- Dondoni
- 2-Thiazolyltrimethylsilane, 2-TST
- CAS:
- 79265-30-8
- MF:
- C6H11NSSi
- MW:
- 157.31
- Product Categories:
-
- Thiazoles, Isothiazoles & Benzothiazoles
- API intermediates
- Si (Classes of Silicon Compounds)
- Si-(C)4 Compounds
- Silicon Compounds (for Synthesis)
- Synthetic Organic Chemistry
- Thiazoles, Isothiazoles &Benzothiazoles
- Building Blocks
- C3 to C7
- Chemical Synthesis
- Heterocyclic Building Blocks
- Thiazoles
- Mol File:
- 79265-30-8.mol
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2-(Trimethylsilyl)thiazole Chemical Properties
- Boiling point:
- 56-57 °C10 mm Hg(lit.)
- Density
- 0.985 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.497(lit.)
- Flash point:
- 135 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- THF: very soluble(lit.)
- form
- Liquid
- pka
- 2.91±0.10(Predicted)
- Specific Gravity
- 0.99
- color
- Clear colorless to slightly yellow
- Water Solubility
- IMMISCIBLE
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 3538017
- CAS DataBase Reference
- 79265-30-8(CAS DataBase Reference)
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Safety Information
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 23-24/25-26
- RIDADR
- 1993
- WGK Germany
- 3
- F
- 10-21
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29341000
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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2-(Trimethylsilyl)thiazole Usage And Synthesis
Chemical Properties
Colorless to light yellow liqui
Physical properties
bp 51–53 °C/10 mmHg; d 0.992 g mL?1; nD 1.4980.
Uses
2-(Trimethylsilyl)thiazole is used as formyl anion equivalent; effective one-carbon homologating reagent of alkoxy aldehydes, amino aldehydes, and dialdoses.It takes part in the reactions of Homologation of Aldehydes, Metalation and Reactivity with Electrophiles, Cross-coupling Reactions, etc.
Preparation
Although 2-(trimethylsilyl)thiazole (1) is commercially available, it can be easily prepared on a multigram scale from 2-bromothiazole, n-butyllithium, and chlorotrimethylsilane as shown in eq 1.
2-(Trimethylsilyl)thiazoleSupplier
New Energy Chemicals Gold
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2-(Trimethylsilyl)thiazole(79265-30-8)Related Product Information
- 1,3-Thiazole-2-carbaldehyde
- Lithium bis(trimethylsilyl)amide
- Thiazole
- Hexamethyldisilazane
- N-(Trimethylsilyl)acetamide
- 2-Methyl-4-isothiazolin-3-one
- Trimethylsilylacetylene
- Silicone rubber,methyl-vinyl
- 2,5-Bis(trimethylsilyl)thiazole, 96%
- 2-(tert-Butyldimethylsilyl)thiazole
- 2-(TRIMETHYLSILYL)BENZOTHIAZOLE
- 2-TRIMETHYLSILANYL-5-TRIMETHYL-STANNANYL-THIAZOLE
- 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE
- 2-(Trimethylsilyl)thiazole
- 2-Bromo-4-chloro-5-(trimethylsilyl)thiazole
- 2,4-Dichloro-5-(trimethylsilyl)thiazole
- 2,4-Dibromo-5-(trimethylsilyl)thiazole