1-(2-Chlorophenyl)piperazine hydrochloride Chemical Properties

Melting point:

160-163 °C (dec.)(lit.)

storage temp. 

Store at room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White

Sensitive 

Hygroscopic

BRN 

5652889

CAS DataBase Reference

41202-32-8(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-(2-Chlorophenyl)piperazine hydrochloride Usage And Synthesis

Uses

1-(2-Chlorophenyl)piperazine Hydrochloride is a reactant used in the preparation of piperazinyl, phenylpiperidinyl, tetrahydropyridinyl, and tetrahydropyridoindolylbutylbenzindoles with 5-hydroxytryptamine receptor antagonist activity.

Synthesis

To a stirred solution of tert-butyl 4-(2-chlorophenyl)piperazine-1-carboxylate (250 mg, 0.844 mmol) in 1,4-dioxane (2 mL) was added slowly and dropwise a 1,4-dioxane solution (0.9 mL, 3.60 mmol) in 4 N HCl at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 h (complete consumption of feedstock was confirmed by TLC monitoring). Upon completion of the reaction, the volatile solvent was removed under reduced pressure to give the crude product. The crude product was washed with ether (2 x 20 mL) and dried under high vacuum to yield 1-(2-chlorophenyl)piperazine hydrochloride (165 mg, 84% yield) as a white solid.

References

[1] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 45; 46

1-(2-Chlorophenyl)piperazine hydrochloride(41202-32-8)Related Product Information

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• DEHYDRO ARIPIPRAZOLE