IDAZOXAN HYDROCHLORIDE
IDAZOXAN HYDROCHLORIDE Basic information
- Product Name:
- IDAZOXAN HYDROCHLORIDE
- Synonyms:
-
- (+/-)-Idazoxan Monohydrochloride
- 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
- RX 781094A
- 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
- IDAZOXAN HYDROCHLORIDE
- 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
- IdazoxanHCl
- RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
- CAS:
- 79944-56-2
- MF:
- C11H13ClN2O2
- MW:
- 240.69
- Product Categories:
-
- Adrenoceptor
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 79944-56-2.mol
IDAZOXAN HYDROCHLORIDE Chemical Properties
- Melting point:
- 207-208°
- storage temp.
- Store at RT
- solubility
- H2O: 300 mg/mL
- form
- Powder
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Hygroscopic
MSDS
- Language:English Provider:SigmaAldrich
IDAZOXAN HYDROCHLORIDE Usage And Synthesis
Chemical Properties
mp 207-209°C
Uses
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
Uses
Antiparkinsonian;Alpha2 agonist
Uses
An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
Biological Activity
α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
Biochem/physiol Actions
α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
IDAZOXAN HYDROCHLORIDESupplier
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IDAZOXAN HYDROCHLORIDE(79944-56-2)Related Product Information
- 2-PHENOXYPROPYLAMINE HYDROCHLORIDE
- 2-METHOXYACETAMIDINE HYDROCHLORIDE
- 2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYLAMINE
- 2-Isopropoxyphenol
- propionamidine hydrochloride
- 2-(2-Methoxyphenoxy)ethylamine
- 2-PHENOXYACETAMIDINE HYDROCHLORIDE
- 1,4-Benzodioxan
- 2-(2-METHOXYPHENOXY)-N-METHYLETHYLAMINE
- 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98
- Idazoxan
- AKOS BBS-00007965
- CHEMBRDG-BB 9070636
- 1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL-
- 2-HYDROXY-PROPIONAMIDINE
- CHEMBRDG-BB 5482082
- 1-AMINO-3-PHENOXY-PROPAN-2-OL
- 2-HYDROXY-ACETAMIDINE HCL