Basic information Safety Supplier Related

IDAZOXAN HYDROCHLORIDE

Basic information Safety Supplier Related

IDAZOXAN HYDROCHLORIDE Basic information

Product Name:
IDAZOXAN HYDROCHLORIDE
Synonyms:
  • (+/-)-Idazoxan Monohydrochloride
  • 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride
  • RX 781094A
  • 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride
  • IDAZOXAN HYDROCHLORIDE
  • 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE
  • IdazoxanHCl
  • RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
CAS:
79944-56-2
MF:
C11H13ClN2O2
MW:
240.69
Product Categories:
  • Adrenoceptor
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
79944-56-2.mol
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IDAZOXAN HYDROCHLORIDE Chemical Properties

Melting point:
207-208°
storage temp. 
Store at RT
solubility 
H2O: 300 mg/mL
form 
Powder
color 
White to off-white
Water Solubility 
Soluble to 100 mM in water
Stability:
Hygroscopic
InChI
InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChIKey
MYUBYOVCLMEAOH-UHFFFAOYSA-N
SMILES
C1(COC2C=CC=CC=2O1)C1=NCCN1.Cl
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
7
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3

MSDS

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IDAZOXAN HYDROCHLORIDE Usage And Synthesis

Chemical Properties

mp 207-209°C

Uses

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Uses

Antiparkinsonian;Alpha2 agonist

Uses

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

in vivo

Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg. Idazoxan (0.3 and 2.5?mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].

Animal Model:Male CD-COBS rats injected with 1?mg/kg haloperidol[1]
Dosage:0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0?mg/kg
Administration:Subcutaneous injection; for 1 hour
Result:Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25?mg/kg.

IC 50

α adrenergic receptor

IDAZOXAN HYDROCHLORIDESupplier

shanghai Gold
Tel
17354719950
Email
sales@fultrachem.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
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IDAZOXAN HYDROCHLORIDE(79944-56-2)Related Product Information