PI 828 Chemical Properties

Boiling point:

534.2±50.0 °C(Predicted)

Density 

1.316±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble

pka

4.14±0.10(Predicted)

form 

Off-white solid

PI 828 Usage And Synthesis

Definition

ChEBI: 8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of chromones.

General Description

A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC₅₀ in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.

Biological Activity

PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase.

storage

Store at +4°C

PI 828(942289-87-4)Related Product Information

• Phenyl carbamate
• 2-(Dimethylamino)-8-phenyl-4H-1-benzopyran-4-one
• LY 294002 HYDROCHLORIDE
• PI 828
• 4H-1-Benzopyran-4-one, 2-(diethylamino)-
• 2-(Diethylamino)-8-phenyl-4H-1-benzopyran-4-one
• 2-(Etilmetilammino)-8-fenilcromone [Italian]