7,3',4'-Trihydroxy-3-benzyl-2H-chroMene Chemical Properties

Boiling point:

540.8±50.0 °C(Predicted)

Density 

1.406±0.06 g/cm3(Predicted)

pka

9.75±0.20(Predicted)

form 

Solid

color 

Brown to black

7,3',4'-Trihydroxy-3-benzyl-2H-chroMene Usage And Synthesis

Uses

7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 μM [H1N1], 39.5 μM [H3N2], and 50.5μM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus[1][2].

References

[1] Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35(5):786-90. DOI:10.1248/bpb.35.786
[2] Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62(3):325-7. DOI:10.1007/s11418-008-0231-6

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