KGN Chemical Properties

Melting point:

272 °C

Boiling point:

464.4±38.0 °C(Predicted)

Density 

1.289±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: >15mg/mL

form 

powder

pka

3.45±0.36(Predicted)

color 

White

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

InChIKey

SLUINPGXGFUMLL-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-36-50/53

Safety Statements 

60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

HS Code 

2916310090

KGN Usage And Synthesis

Description

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC₅₀ value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.

Uses

Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

storage

+4°C

References

1) Johnson et al. (2012), A stem cell-based approach to cartilage repair; Science, 336 717

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