KGN

Product Name: KGN
CAS No.: 4727-31-5
Chemical Name: KGN
Synonyms: KGN;CS-612;100822;Kartogenin;KGN USP/EP/BP;Kartogenin(KGN);4'-Phenylphthalanilic Acid;n-Biphenyl-4-yl-phthalamic acid;4′-Phenyl-phthalanilic acid (8CI);2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
CBNumber: CB52622751
Molecular Formula: C20H15NO3
Formula Weight: 317.34
MOL File: 4727-31-5.mol

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KGN Property

Melting point:: 272 °C
Boiling point:: 464.4±38.0 °C(Predicted)
Density: 1.289±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >15mg/mL
form: powder
pka: 3.45±0.36(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey: SLUINPGXGFUMLL-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-36-50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2916310090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0370
Product name: Kartogenin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0370
Product name: Kartogenin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $441
Updated: 2024/03/01

Cayman Chemical

Product number: 11826
Product name: Kartogenin
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 11826
Product name: Kartogenin
Purity: ≥98%
Packaging: 10mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 11826
Product name: Kartogenin
Purity: ≥98%
Packaging: 25mg
Price: $261
Updated: 2024/03/01

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KGN Chemical Properties,Usage,Production

Description

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC₅₀ value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.

Uses

Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

storage

+4°C

References

1) Johnson et al. (2012), A stem cell-based approach to cartilage repair; Science, 336 717

KGN Preparation Products And Raw materials

Raw materials

Preparation Products

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KGN Suppliers

China 118 India 2 United Kingdom 3 United States 18 Global 141

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

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View Lastest Price from KGN manufacturers

Career Henan Chemical Co

Product: 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid 4727-31-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

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2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid

2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid

Kartogenin(KGN)

4'-Phenylphthalanilic Acid

Kartogenin

KGN

2-([1,1'-biphenyl]-4-ylcarbaMoyl)benzoic acid

4′-Phenyl-phthalanilic acid (8CI)

n-Biphenyl-4-yl-phthalamic acid

100822

CS-612

2-[(4-phenylphenyl)carbamoyl]benzoic Acid

Benzoic acid, 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-

KGN USP/EP/BP

2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid

4727-31-5

Inhibitors

API