4-PIPERIDIN-1-YL-BENZALDEHYDE Chemical Properties

Melting point:

61-64 °C

Boiling point:

344.3±25.0 °C(Predicted)

Density 

1.091±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.88±0.20(Predicted)

form 

solid

color 

Yellow

InChIKey

ILJVPSVCFVQUAD-UHFFFAOYSA-N

CAS DataBase Reference

10338-57-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

4-PIPERIDIN-1-YL-BENZALDEHYDE Usage And Synthesis

Uses

Reactant for synthesis of:

• Anti-inflammatory agents
• Piperidine incorporated α-aminophosphonates for antibacterial agents
• 5-Hydroxyaurone derivatives as growth inhibitors against HUVEC and some cancer cell lines
• NR2B selective NMDA receptor antagonists
• Fulleropyrrolidines
• Fluorophores for monitoring polymerization processes

Synthesis

General procedure for the synthesis of 4-piperidin-1-yl-benzaldehyde from hexahydropyridine and p-fluorobenzaldehyde: A mixture of p-fluorobenzaldehyde (25.0 g, 0.200 mol), hexahydropyridine (0.300 mol), and anhydrous potassium carbonate (40.0 g) was mixed in DMF (300 mL) and a catalytic amount of Aliquat 336 reagent was added. The reaction mixture was refluxed at 100 °C for 24 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure and cooled to room temperature. Subsequently, the mixture was poured into ice water and allowed to stand overnight. The solid product formed was filtered, washed with water and recrystallized with methanol to afford the target compound 4-(piperidin-1-yl)benzaldehyde. The compound was obtained in 98% yield as yellow crystals with a melting point of 64°C, which is in agreement with literature reports [47,48].

References

[1] Bioorganic Chemistry, 2014, vol. 57, p. 65 - 82
[2] Russian Journal of General Chemistry, 2013, vol. 83, # 10, p. 1864 - 1868
[3] Zh. Obshch. Khim., 2013, vol. 83, # 10, p. 1654 - 1659,6
[4] Oriental Journal of Chemistry, 2013, vol. 29, # 4, p. 1531 - 1534
[5] European Journal of Organic Chemistry, 2017, vol. 2017, # 35, p. 5219 - 5224

4-PIPERIDIN-1-YL-BENZALDEHYDE(10338-57-5)Related Product Information

• Ipodate Sodium
• 4-PIPERIDIN-1-YL-BENZOIC ACID
• 4'-PIPERIDINOACETOPHENONE
• 4-PIPERIDIN-1-YL-BENZALDEHYDE
• 3-NITRO-4-PIPERIDINOBENZALDEHYDE
• 2-PIPERIDIN-1-YL-BENZALDEHYDE, 95+%,2-PIPERIDIN-1-YL-BENZALDEHYDE
• 1-(3-AMINO-4-PIPERIDINOPHENYL)-1-ETHANONE
• 1-(3-NITRO-4-PIPERIDINOPHENYL)-1-ETHANONE
• 3-NITRO-4-PIPERIDIN-1-YLBENZOIC ACID
• ETHYL 1-(4-ACETYL-2-NITROPHENYL)-4-PIPERIDINECARBOXYLATE
• 1-(4-ACETYLPHENYL)-4-PIPERIDINECARBOXYLIC ACID
• 2-CHLORO-4-PIPERIDIN-1-YL-BENZALDEHYDE
• 2-ETHOXY-4-PIPERIDIN-1-YL-BENZALDEHYDE
• 2-METHYL-4-PIPERIDIN-1-YL-BENZALDEHYDE
• 4-(3-METHYL-PIPERIDIN-1-YL)-BENZALDEHYDE
• 4-[4-(Hydroxymethyl)piperidin-1-yl]benzaldehyde
• 2-METHOXY-4-PIPERIDIN-1-YL-BENZALDEHYDE
• 1-[4-(4-([4-(4-METHOXYPHENYL)PIPERAZINO]CARBONYL)PIPERIDINO)PHENYL]-1-ETHANONE