SUN11602
SUN11602 Basic information
- Product Name:
- SUN11602
- Synonyms:
-
- SUN11602
- 4-[[4-[[2-[(4-Amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]benzamide
- CS-2504
- SUN11602;SUN11602
- inhibit,Fibroblast growth factor receptor,SUN11602,FGFR,Inhibitor,SUN-11602
- Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]-
- SUN11602, 10 mM in DMSO
- CAS:
- 704869-38-5
- MF:
- C26H37N5O2
- MW:
- 451.60428
- Mol File:
- 704869-38-5.mol
SUN11602 Chemical Properties
- Boiling point:
- 679.8±55.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- pka
- 16.19±0.50(Predicted)
- color
- Light yellow to yellow
SUN11602 Usage And Synthesis
Uses
SUN 11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor.
Biological Activity
SUN11602 is an orally active basic fibroblast growth factor (bFGF, FGF2) mimetic th at protects against glutamate toxicity in primary r at cerebrocortical neuron (0.1-1 μM SUN11602; 150 μM glutamate) and murine hippocampal neuron cultures (0.3-3 μM SUN11602; 100 μM glutamate). When administered in vivo, SUN11602 exhibits therapeutic efficacy in a r at hippocampal-lesion model (1-10 mg/kg p.o. 24h post Aβ1-40 injection) and a murine MPTP-induced nigrostriatal degeneration model (2.5-5 mg/kg/day p.o.).
in vivo
In WT mice, SUN11602 increases the levels of newly synthesized Calb in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca2+. This Ca2+-capturing ability of Calb allows the neurons to survive severe toxic conditions of glutamate[1]. Oral administration of SUN11602 at the midpoint of Aβ1-40 and ibotenate injections attenuate short-term memory impairment in the Y-maze test, as well as spatial learning deficits in the water maze task. In addition, the SUN11602 treatment inhibits the increase of peripheral-type benzodiazepine-binding sites (PTBBS),which are a marker for gliosis[3].
SUN11602Supplier
- Tel
- sales@boylechem.com
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- 021-52996696，15000506266 15000506266
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- 021-61350663 13052117465
- sales@zehanbiopharma.com
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- 021-61312847; 18021002903
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