D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 Basic information
- Product Name:
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- Synonyms:
-
- pro(4)-trp(7,9)-substancep(4-11
- (D-PRO4,D-TRP7,9)-SUBSTANCE P (4-11)
- [D-PRO4,D-TRP7,9]-SUBSTANCE P (4-11) ACOH 4H2O
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 ACOH 4H2O
- H-D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- substance P (4-11), Pro(4)-Trp(7,9)-
- Substance P, [D-Pro4, D-Trp7,9]
- CAS:
- 81039-85-2
- MF:
- C57H75N13O10S
- MW:
- 1134.35
- Mol File:
- 81039-85-2.mol
D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 Usage And Synthesis
Uses
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration[1].
in vivo
[D-Pro4,D-Trp7,9] Substance P (4-11) inhibits the hypotensive effect of Substance P in anesthetized rats, the vasodilator effect in the rabbit perfused heart, relaxation induced by Substance P in dog carotid arteries contracted with noradrenaline, and stimulatory actions of Substance P in the guinea pig ileum and the guinea pig trachea[1]. [D-Pro4,D-Trp7,9] Substance P (4-11) (0.3 nM/K/min; i.p. for 7 days) significantly decreases plasma aldosterone (ALDO) concentration and causes atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells[2].
References
[1] Mizrahi J, et al. Substance P antagonists active in vitro and in vivo. Eur J Pharmacol. 1982 Aug 13;82(1-2):101-5. DOI:10.1016/0014-2999(82)90561-1
[2] Mazzocchi G, et al. Evidence that endogenous substance-P (SP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa. Neuropeptides. 1995 Jul;29(1):53-8. DOI:10.1016/0143-4179(95)90056-x
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D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2(81039-85-2)Related Product Information
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-NLE-NH2
- SUBSTANCE P (4-11)
- H-ARG-D-TRP-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2,ARG-D-TRP-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2
- [D-PRO2, D-TRP7,9]-SUBSTANCE P
- ARG-D-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2 ACETATE SALT
- D-Prolinamide
- 2,2-DIMETHYL-2,3-DIHYDRO-1-BENZOFURAN-7-CARBALDEHYDE
- D-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-MET-NH2