4-Oxo-TEMPO Chemical Properties

Melting point:

33-38 °C

Boiling point:

299.88°C (rough estimate)

Density 

1.0710 (rough estimate)

vapor pressure 

2.254Pa at 25℃

refractive index 

1.4640 (estimate)

storage temp. 

2-8°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml

form 

Needles, Crystals or Crystalline Powder

color 

Orange

Water Solubility 

Soluble in water (partly), acetone, DMSO, 100% ethanol, and diethylether. Insoluble in water.

BRN 

1818579

LogP

0.28 at 22℃

CAS DataBase Reference

2896-70-0(CAS DataBase Reference)

NIST Chemistry Reference

1-Piperidinyloxy, 2,2,6,6-tetramethyl-4-oxo-(2896-70-0)

EPA Substance Registry System

1-Piperidinyloxy, 2,2,6,6-tetramethyl-4-oxo- (2896-70-0)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

TN9200000

TSCA 

Yes

HS Code 

29333990

MSDS

• Language:English Provider:4-Oxo-TEMPO
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Oxo-TEMPO Usage And Synthesis

Description

2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS). This conversion, followed by ESR, provides an indirect way to monitor ROS production in biological systems. TEMPONE is the 4-oxo derivative of TEMPO. In addition to possible uses as a spin trap, this nitroxyl radical can be used in hydrogen transfer experiments and as a polarizing agent in dynamic nuclear polarization NMR spectroscopy. TEMPONE and other nitroxyl radicals have also been shown to reduce mean arterial pressure in spontaneously hypertensive rats when administered intravenously.

Chemical Properties

Pink Needles

Uses

A spin label for ESR studies

Uses

Free-radical nitroxide spin probe typically used for:

• Redox sources for anodes in lithium secondary batteries
• Free-radical biological studies
• Radical spin-trapping
• Electron paramagnetic resonance studies
• Polymer chemisty and synthesis applications

General Description

4-Oxo-TEMPO is formed by the reaction of 2,2,6,6-tetramethyl-4-piperidone (4-oxo-TMP) and ¹O₂. It is a stable paramagnetic product formed during the irradiation of TiO₂ in aqueous suspensions.

Flammability and Explosibility

Non flammable

4-Oxo-TEMPO(2896-70-0)Related Product Information

• Triacetonediamine
• 2,2,6,6-Tetramethylpiperidine
• 1,1'-Carbonyldiimidazole
• 2,2,6,6-Tetramethyl-4-piperidinol
• PENICILLIN V
• 2,2,6,6-Tetramethylpiperidinooxy
• 4-Methylenepiperidine HCl
• 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine
• Carbonyl iron powder
• 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidin-1-yl
• 4-OXO-2,2,6,6-TETRAMETHYLPIPERIDINE-D16-1-OXYL
• 4-OXO-2,2,6,6-TETRAMETHYLPIPERIDINE-D16,1-15N-1-OXYL
• 4-Oxo-2,2,6,6-tetramethylpiperidinooxy
• 1-Acetyloxy-2,2,6,6-tetramethyl-4-oxopiperidine
• 4-OXO-2,2,6,6-TETRAMETHYLPIPERIDINE-1-15N-1-OXYL
• 1-HYDROXY-2 2 6 6-TETRAMETHYL-4-PIPERI-
• 1-Benzoyloxy-2,2,6,6-tetramethyl-4-oxopiperidine