Basic information Safety Supplier Related

Alverine

Basic information Safety Supplier Related

Alverine Basic information

Product Name:
Alverine
Synonyms:
  • n-ethyl-n-(3-phenylpropyl)benzenepropanamine
  • SESTRON
  • Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-
  • di(phenylpropyl)ethylamine
  • dipropylin
  • n-ethyl-3,3’-diphenyl-dipropylamin
  • n-ethyl-3,3’-diphenyldipropylamine
  • N-Ethyl-3,3'-diphenyldipropylamine
CAS:
150-59-4
MF:
C20H27N
MW:
281.44
EINECS:
205-763-5
Mol File:
150-59-4.mol
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Alverine Chemical Properties

Melting point:
<25 °C
Boiling point:
bp0.3 165-168°; bp13 210-215°
Density 
0.973±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
pka
9.51±0.50(Predicted)
NIST Chemistry Reference
Benzenepropanamine, n-ethyl-n-(3-phenylpropyl)-(150-59-4)
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Safety Information

Hazardous Substances Data
150-59-4(Hazardous Substances Data)
Toxicity
women,TDLo,oral,126mg/kg/5W-I (126mg/kg),BEHAVIORAL: ANOREXIA (HUMANLIVER: LIVER FUNCTION TESTS IMPAIREDLIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE",Journal of Hepathology. Vol. 27, Pg. 399, 1997.
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Alverine Usage And Synthesis

Originator

Alverine citrate,Kemikos

Uses

Anticholinergic.

Definition

ChEBI: A tertiary amine having one ethyl and two 3-phenylprop-1-yl groups attached to the nitrogen. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used (particularly as the citrate salt) in the treatment of irritable bowel synd ome.

Manufacturing Process

2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
In practice it is usually used as citrate.

Therapeutic Function

Anticholinergic, Spasmolytic

AlverineSupplier

Clearsynth Labs Limited
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Synchem OHG
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+49 5662 408730
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Shanghai HuanChuan Industry Co.,Ltd.
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021-61478794
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sales@hcshhai.com
Aikon International Limited
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025-66113011 18112977050
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Chengdu Saint - Kay Biotechnology Co., Ltd.
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028-85157043 15882256948
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676046971@qq.com
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Alverine(150-59-4)Related Product Information