Alverine citrate Chemical Properties

Melting point:

100-102°

storage temp. 

2-8°C

solubility 

Slightly soluble in water and in methylene chloride, sparingly soluble in ethanol (96 per cent).

color 

White to Off-White

InChIKey

RYHCACJBKCOBTJ-UHFFFAOYSA-N

CAS DataBase Reference

5560-59-8(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29214990

MSDS

• Language:English Provider:SigmaAldrich

Alverine citrate Usage And Synthesis

Chemical Properties

White or almost white, crystalline powder.

Originator

Alverine citrate,Kemikos

Uses

Used for studies of pharmacological activity including:

• Synergism with fluconazole against Saccharomyces cerevisiae and Candida albicans
• Efficacy of combination with simeticone on abdominal pain associated with irritable bowel syndrome
• Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis
• Drug effects viewed from a signal transduction network perspective
• Enhanced cytotoxic effect of proteasome inhibitor MG132
• Mechanism of action on phasic smooth muscles

Uses

An adrenergic-β3 receptor agonist. Antispasmodic.

Uses

anticholinergic

Definition

ChEBI: The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in the treatment of irritable bowel syndrome.

Manufacturing Process

2 Methods of producing of alverine:
1. 3-Phenylpropylchloride reacted with ethylamine in the presence potassium hydroxide and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
2. 3-Phenylpropenal reacted with ethylamine in the presence hydrogen and Pt as catalyst and BaSO4 and N-ethyl-3,3'-diphenyldipropylamine (alverine) was obtained.
In practice it is usually used as citrate.

Therapeutic Function

Anticholinergic, Spasmolytic

Alverine citrate(5560-59-8)Related Product Information

• Ethyl acetate
• Sodium citrate
• BISMUTH POTASSIUM CITRATE
• Calcium citrate
• Citric acid monohydrate
• Potassium Citrate
• Ethanol
• Ethylparaben
• Sildenafil citrate
• Alverine
• TAMOXIFEN CITRATE(RG)
• D/L-AMPHETAMINE HYDROCHLORIDE
• 3-METHYLGLUTARIC ACID
• Citric acid
• TRICARBALLYLIC ACID
• (S)-(+)-CITRAMALIC ACID
• 2-Hydroxyisobutyric acid
• (R)-(-)-CITRAMALIC ACID