(R)-(-)-CITRAMALIC ACID Chemical Properties

Melting point:

108-110 °C(lit.)

Boiling point:

188.68°C (rough estimate)

Density 

1.2336 (rough estimate)

refractive index 

1.3920 (estimate)

storage temp. 

2-8°C

solubility 

PBS (pH 7.2): 10 mg/ml

pka

3.65±0.28(Predicted)

form 

powder or crystals

optical activity

[α]/D -19.0±1.0°, c = 0.5 in 1 M HCl

Merck 

2323

BRN 

1723818

CAS DataBase Reference

6236-10-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

MSDS

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• Language:English Provider:SigmaAldrich

(R)-(-)-CITRAMALIC ACID Usage And Synthesis

Chemical Properties

white fine crystalline powder

Definition

ChEBI: D-citramalic acid is the D-enantiomer of citramalic acid. It is a conjugate acid of a D-citramalate(2-).

Biological Activity

Citramalate is a biochemical intermediate known to be involved in several aspects of bacterial metabolism, including, among others, the anaerobic metabolism of glutamate via the methylaspartate pathway of Clostridium tetanomorphum.

References

[1] D M HOWELL  R H W  H Xu. (R)-citramalate synthase in methanogenic archaea.[J]. Journal of Bacteriology, 1999, 181 1: 331-333. DOI: 10.1128/jb.181.1.331-333.1999
[2] W BUCKEL  H A B. Two pathways of glutamate fermentation by anaerobic bacteria.[J]. Journal of Bacteriology, 1974, 117 3: 1248-1260. DOI: 10.1128/jb.117.3.1248-1260.1974
[3] SILKE FRIEDMANN  Georg F  Birgit E Alber. Properties of succinyl-coenzyme A:D-citramalate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.[J]. Journal of Bacteriology, 2006, 188 18: 6460-6468. DOI: 10.1128/jb.00659-06

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