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Aprepitant Impurity 9

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Aprepitant Impurity 9 Basic information

Product Name:
Aprepitant Impurity 9
Synonyms:
  • Aprepitant Impurity 9
  • Aprepitant Open-Ring Methyl Ester Impurity
  • 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]hydrazinecarboxylic acid methyl ester
  • Aprepitant impurity 22/Aprepitant Open-Ring Methyl Ester Impurity
  • Aprepitant Impurity 47
  • Methyl 2-(2-((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl) morpholino)-1-iminoethyl)hydrazinecarboxylate
  • Hydrazinecarboxylic acid, 2-[2-[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]-1-iminoethyl]-, methyl ester
  • methyl 2-(1-amino-2-((2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)ethylidene)hydrazine-1-carboxylate
CAS:
219821-37-1
MF:
C24H25F7N4O4
MW:
566.47
Mol File:
219821-37-1.mol
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Aprepitant Impurity 9 Chemical Properties

Density 
1.43±0.1 g/cm3(Predicted)
solubility 
soluble in Chloroform, Dichloromethane, Methanol
form 
Solid
pka
7.86±0.43(Predicted)
color 
Pale-Yellow
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Aprepitant Impurity 9 Usage And Synthesis

Uses

N-(Destriazolonomethyl), N-(Methylcarboxyacetamidohydrazono) Aprepitant is a derivative of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.

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