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Sitagliptin Impurity 21

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Sitagliptin Impurity 21 Basic information

Product Name:
Sitagliptin Impurity 21
Synonyms:
  • Sitagliptin Fumarate Adduct(Sitagliptin Impurity FP-A)
  • ((R)-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl) aspartic acid
  • Sitagliptin Impurity FP-A
  • Sitagliptin impurity 5/Sitagliptin FP Impurity A/Sitagliptin Fumarate Adduct/Sitagliptin Maleate Adduct/N-[(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]aspartic acid
  • 2-(((R)-4-oxo-4-(3-(trifluoromethyl)
  • Sitagliptin-14
  • Sitagliptin FP Impurity A
  • L-Aspartic acid, N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]-
CAS:
2088771-60-0
MF:
C20H19F6N5O5
MW:
523.39
Mol File:
2088771-60-0.mol
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Sitagliptin Impurity 21 Chemical Properties

Melting point:
149 - 153°C
Boiling point:
673.9±65.0 °C(Predicted)
Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
2.05±0.23(Predicted)
form 
Solid
color 
White to Off-White
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Sitagliptin Impurity 21 Usage And Synthesis

Uses

Sitagliptin Fumarate Adduct is an impurity of Sitagliptin (S491000), a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

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