Ripretinib Chemical Properties

Boiling point:

568.6±50.0 °C(Predicted)

Density 

1.544±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:25.0(Max Conc. mg/mL);49.0(Max Conc. mM)

form 

A solid

pka

12.15±0.70(Predicted)

color 

White to light yellow

Ripretinib Usage And Synthesis

Uses

Ripretinib is used in the treatment of gastrointestinal stromal tumors (GISTs).

brand name

Qinlock

General Description

Class: receptor tyrosine kinase; Treatment: GIST; Other name: DCC-2618; Elimination half-life = 15 h; Protein binding = 98.8%

Biological Activity

Ripretinib is a highly effective inhibitor of both wild-type KIT and PDGFRA, with IC50 values around 3 nM. It also targets a wide range of KIT and PDGFRA mutants in GIST. Additionally, it inhibits various tumor-driving kinases such as PDGFRβ, TIE2, VEGFR2, and BRAF.

target

Primary targets: PDGFRA, KIT

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