wu
wu Basic information
- Product Name:
- wu
- Synonyms:
-
- PLX51109
- PXL51107
- PLX51107
- PLX51107;PLX 51107;PLX-51107
- CS-2690
- PXL 51107 ;PXL-51107
- 4-[6-(3,5-Dimethyl-4-isoxazolyl)-1-[(1S)-1-(2-pyridinyl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]benzoic Acid
- Benzoic acid, 4-[6-(3,5-dimethyl-4-isoxazolyl)-1-[(1S)-1-(2-pyridinyl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]-
- CAS:
- 1627929-55-8
- MF:
- C26H22N4O3
- MW:
- 438.48
- Mol File:
- 1627929-55-8.mol
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wu Chemical Properties
- Melting point:
- >270°C (dec.)
- Boiling point:
- 683.3±55.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly, Heated)
- pka
- 3.68±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChIKey
- AMSUHYUVOVCWTP-INIZCTEOSA-N
- SMILES
- C(O)(=O)C1=CC=C(C2C3=NC=C(C4=C(C)ON=C4C)C=C3N([C@H](C3=NC=CC=C3)C)C=2)C=C1
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wu Usage And Synthesis
Uses
4-[6-(3,5-Dimethyl-4-isoxazolyl)-1-[(1S)-1-(2-pyridinyl)ethyl]-1H-pyrrolo[3,2-b]pyridin-3-yl]benzoic Acid, is a potent and selective BET inhibitor.
in vivo
PLX51107 (2 mg/kg, p.o.) inhibits splenomegaly by 75% in the Ba/F3 (murine IL3-dependent pro-B-cell line) splenomegaly mouse model, with the similar effect of 25 mg/kg OTX015. PLX51107 (20 mg/kg, qd, p.o.) exhibits potent antileukemic effects in disease models of aggressive chronic lymphocytic leukemia (CLL) and Richter transformation (RT) via oral administration once daily[1].
wuSupplier
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Beijing Ouhe Technology Co., Ltd
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- 010-010-82967028 13522913783
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Dalian Meilun Biotech Co., Ltd.
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- 0411-62910999 13889544652
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com