VALERIC ANHYDRIDE Chemical Properties

Melting point:

-56 °C (lit.)

Boiling point:

228-230 °C (lit.)

Density 

0.944 g/mL at 20 °C (lit.)

vapor pressure 

5Pa at 25℃

refractive index 

n20/D 1.421(lit.)

Flash point:

214 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

Specific Gravity

0.945-0.95 (20.00 °C)

color 

Clear colorless to yellow

Water Solubility 

486.3 mg/L (25 °C,est)

BRN 

1770130

InChI

1S/C10H18O3/c1-3-5-7-9(11)13-10(12)8-6-4-2/h3-8H2,1-2H3

InChIKey

DUCKXCGALKOSJF-UHFFFAOYSA-N

SMILES

CCCCC(=O)OC(=O)CCCC

LogP

3.33 at 25℃

CAS DataBase Reference

2082-59-9(CAS DataBase Reference)

EPA Substance Registry System

Pentanoic acid, anhydride (2082-59-9)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3265 8/PG 3

WGK Germany 

3

TSCA 

TSCA listed

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

VALERIC ANHYDRIDE Usage And Synthesis

Description

Valeric anhydride is an important organic synthetic raw material or intermediate component, often used in industrial or medical fields. It can be used in the preparation of butylphthalide, resin components, lutein esters, analgesics and organic glass.

Chemical Properties

clear colorless to yellow liquid

Uses

Valeric Anhydride is used in the synthesis of non-imadazole histamine H3-antagonists. Also used in the preparation of millepachine derivatives as a new class of tubulin polymerization inhibitors.

Uses

Valeric anhydride can be used as a reactant to synthesize:

• Alkyl 9-nitrocamptothecin esters by the esterification reaction.
• Modified bismuth metal-organic frameworks (Bi-MOFs).
• O-acylated chitosan nanofibers (CSNFs) for potential usage in biomaterials and food packaging.

Preparation

Valeric anhydride was obtained by a treatment of the anhydrous sodium valerate by acid chloride of valeric acid^[1].

Hazard

Valeric anhydride is a colourless liquid that is corrosive and irritant. Contact may lead to severe eye irritation. Skin contact may cause severe skin burns and may also trigger allergic skin reactions.

Flammability and Explosibility

Non flammable

References

[1] T. S. Kotel’nikova. (2009). Kinetics of alcoholysis of valeric anhydride by cyclohexanol in the presence of formic acid. Russian Journal of Applied Chemistry, 82 3, 466–472. https://doi.org/10.1134/S1070427209030227

VALERIC ANHYDRIDE(2082-59-9)Related Product Information

• N-VALERIC ACID CIS-3-HEXEN-1-YL ESTER
• PENTYL VALERATE
• HEXANOIC ANHYDRIDE
• MYRISTIC ANHYDRIDE
• LAURIC ANHYDRIDE
• VALERIC ANHYDRIDE
• RUBRATOXIN B
• STEARIC ANHYDRIDE
• Palmitic anhydride
• DECANOIC ANHYDRIDE
• OLEIC ANHYDRIDE
• N-CAPRYLIC ANHYDRIDE
• BEHENIC ANHYDRIDE
• 2-ETHYLHEXANOIC ANHYDRIDE
• HEPTANOIC ANHYDRIDE
• 2-PHENYLGLUTARIC ANHYDRIDE
• 2,2-DIMETHYLGLUTARIC ANHYDRIDE
• ISOVALERIC ANHYDRIDE
• Pentanoic Anhydride