2-Methyl-1,3-thiazole-4-carboxylic acid Chemical Properties

Melting point:

148 °C

Boiling point:

301.2±15.0 °C(Predicted)

Density 

1.418±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

powder to crystal

pka

4.28±0.10(Predicted)

color 

White to Light yellow

CAS DataBase Reference

35272-15-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

2

HazardClass 

IRRITANT

HS Code 

29341000

2-Methyl-1,3-thiazole-4-carboxylic acid Usage And Synthesis

Chemical Properties

White to orange to tan solid

Synthesis

The general procedure for the synthesis of 2-methyl-4-thiazolecarboxylic acid using ethyl 2-methylthiazole-4-carboxylate as starting material is as follows: 1. dissolve ethyl 2-methylthiazole-4-carboxylate in tetrahydrofuran (THF). 2. add 10% (w/v) aqueous solution of potassium hydroxide (KOH) to the above solution. 3. The reaction mixture was stirred at room temperature until thin layer chromatography (TLC) showed complete disappearance of the raw material. 4. pH of the reaction solution was adjusted to 4 with 1 M hydrochloric acid (HCl). 5. The reaction solution was extracted with ethyl acetate (EtOAc). 6. 6. The organic phase was dried with anhydrous magnesium sulfate (MgSO?). 7. The organic phase was concentrated to give the target product 2-methyl-4-thiazolecarboxylic acid.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 776 - 788
[2] Patent: US2007/105891, 2007, A1. Location in patent: Page/Page column 10
[3] Patent: US2006/160857, 2006, A1. Location in patent: Page/Page column 31
[4] Chemistry of Heterocyclic Compounds, 2011, vol. 47, # 6, p. 703 - 709
[5] Patent: WO2004/58702, 2004, A2. Location in patent: Page 29; 23

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