mPEG5-Propyne Chemical Properties

Boiling point:

349.8±37.0 °C(Predicted)

Density 

1.031±0.06 g/cm3(Predicted)

mPEG5-Propyne Usage And Synthesis

Biological Activity

m-PEG5-Propyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1006.

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