ETHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE Chemical Properties

Melting point:

98-100°C

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

White to off-white Solid

Safety Information

Risk Statements 

22-36/37/38

Safety Statements 

22-26-36/37/39

HS Code 

2916399090

ETHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE Usage And Synthesis

Uses

H-DL-Serine ethyl ester HCl

Synthesis

1. 5.4 mL of thionyl chloride (about two drops) was slowly added dropwise to a 100 mL three-necked flask containing 40 mL of ethanol under an ice-water bath and mechanical stirring, and stirring was continued for 1 hr after completion of the dropwise addition. 2. 6.00 g (57 mmol) of L-serine was added to the above reaction system and the reaction was heated to reflux for 10 hours. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give 9.05 g of the white solid product L-serine ethyl ester hydrochloride (III) in 93.4% yield.

References

[1] Patent: CN105777611, 2016, A. Location in patent: Paragraph 0052; 0053

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