MM 07
MM 07 Basic information
- Product Name:
- MM 07
- Synonyms:
-
- MM 07
- CRPRLCHKGPMPF(Modification: Disulfide bridge: 1-6)
- MM 07 TFA
- CAS:
- 1876450-21-3
- MF:
- C67H106N22O14S3
- MW:
- 1539.91
- Mol File:
- 1876450-21-3.mol
MM 07 Chemical Properties
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- pka
- 3.56±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Souble in water
- Sequence
- Cys-Arg-Pro-Arg-Leu-Cys-His-Lys-Gly-Pro-Met-Pro-Phe (Disulfide bridge:Cys1-Cys6)
MM 07 Usage And Synthesis
Uses
MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.
in vivo
MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr1]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr1]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr1]apelin 13 and MM 07 increases peak velocity above basal levels[1].
References
[1] Brame AL, et al. Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension. 2015 Apr;65(4):834-40. DOI:10.1161/HYPERTENSIONAHA.114.05099
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