Basic information Safety Supplier Related

ZT-12-037-01

Basic information Safety Supplier Related

ZT-12-037-01 Basic information

Product Name:
ZT-12-037-01
Synonyms:
  • ZT-12-037-01
  • 2,4-Quinazolinediamine, N2-cyclopropyl-6,7-dimethoxy-N4-[1-(1-methylethyl)-4-piperidinyl]-
  • inhibit,ZT 12 037 01,ZT1203701,Ras,Inhibitor
  • N2-Cyclopropyl-N4-(1-isopropylpiperidin-4-yl)-6,7-dimethoxyquinazoline-2,4-diamine
CAS:
2328073-61-4
MF:
C21H31N5O2
MW:
385.5
Mol File:
2328073-61-4.mol
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ZT-12-037-01 Chemical Properties

storage temp. 
2-8°C(protect from light)
solubility 
DMSO: 8.33 mg/mL (21.61 mM)
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ZT-12-037-01 Usage And Synthesis

Biological Activity

ZT-12-037-01 is an ATP-competitive STK19 inhibitor with IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. At a concentration of 1 μM, it is highly selective against a kinase library of 468 kinases.

in vitro

Treatment with ZT-12-037-01 could effectively inhibit NRAS phosphorylation. ZT-12-037-01 is an ATP-competitive inhibitor that potently inhibits melanocytic colony formation, proliferation and tumor formation driven by mutant NRAS-STK19. It's pro-apoptotic activity was significantly enhanced in cells expressing oncogenic NRAS.

in vivo

ZT-12-037-01 is a potent STK19 inhibitor with low toxicity in vivo. In the SK-MEL-2 xenograft model (carrying NRAS.

target

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ZT-12-037-01Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Email
sales@zehanbiopharma.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Email
2853530910@QQ.com
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Email
sales@rechemscience.com
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ZT-12-037-01(2328073-61-4)Related Product Information

TargetValue
STK19
(Cell-free assay)
23.96 nM
STK19 (D89N)
(Cell-free assay)
27.94 nM