Z-Vad-fmk, non-methylated Chemical Properties

Boiling point:

758.0±60.0 °C(Predicted)

Density 

1.260±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)

form 

Off-white solid

pka

3.91±0.19(Predicted)

color 

White to light yellow

Z-Vad-fmk, non-methylated Usage And Synthesis

Description

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.

General Description

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.

Biochem/physiol Actions

Product does not compete with ATP.

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