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Z-PHE-DL-ALA-FLUOROMETHYLKETONE

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Z-PHE-DL-ALA-FLUOROMETHYLKETONE Basic information

Product Name:
Z-PHE-DL-ALA-FLUOROMETHYLKETONE
Synonyms:
  • Z-PHE-DL-ALA-FLUOROMETHYLKETONE
  • Carbamic acid,N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl ester
  • Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide z-fa-fmk
  • Nalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide
  • CS-1504
  • Z-Phe-DL-Ala-FMK
  • Benzyl ((2S)-1-((4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
  • SARS coronavirus,SARS-CoV,RRMs,DNA fragmentation,DEVDase,Caspase,Cathepsin,Inhibitor,externalization of phosphatidylserine,Apoptosis,inhibit,Z FA FMK,reovirus replication,ZFAFMK
CAS:
197855-65-5
MF:
C21H23FN2O4
MW:
386.42
Product Categories:
  • Inhibitors
  • API
Mol File:
197855-65-5.mol
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Z-PHE-DL-ALA-FLUOROMETHYLKETONE Chemical Properties

Boiling point:
630.5±55.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMF: 5 mg/ml; DMSO: 5 mg/ml
form 
White solid
pka
11.07±0.46(Predicted)
color 
White to off-white
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Safety Information

HS Code 
29145090
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Z-PHE-DL-ALA-FLUOROMETHYLKETONE Usage And Synthesis

Description

Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 μM) without affecting the initiator caspases-8 and -10. Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses. It can be used both in cells and in vivo.

Uses

Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.

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