Z-PHE-DL-ALA-FLUOROMETHYLKETONE Chemical Properties

Boiling point:

630.5±55.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMF: 5 mg/ml; DMSO: 5 mg/ml

form 

White solid

pka

11.07±0.46(Predicted)

Safety Information

HS Code 

29145090

Z-PHE-DL-ALA-FLUOROMETHYLKETONE Usage And Synthesis

Description

Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-2, -3, -6, and -7 (IC₅₀ = 6-32 μM) without affecting the initiator caspases-8 and -10. Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses. It can be used both in cells and in vivo.

Uses

Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.

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