1400 W DIHYDROCHLORIDE, 96 Chemical Properties

Melting point:

208 °C

storage temp. 

-20°C

solubility 

Soluble in Water (up to 25 mg/ml).

form 

White solid

color 

White

Water Solubility 

Soluble to 100 mM in water

Stability:

Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

HS Code 

29242998

1400 W DIHYDROCHLORIDE, 96 Usage And Synthesis

Description

1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2

Chemical Properties

white to off-white powder

Uses

A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.

Uses

1400W dihydrochloride has been used:

• as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
• as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
• to study its efficacy on renal ischemia/ reperfusion injury in rats
• as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

General Description

A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; K_d = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.

Biochem/physiol Actions

Cell permeable: yes

storage

Desiccate at RT

References

References/Citations 1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959 2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300 3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255

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