1400 W DIHYDROCHLORIDE, 96
- Product Name
- 1400 W DIHYDROCHLORIDE, 96
- CAS No.
- 214358-33-5
- Chemical Name
- 1400 W DIHYDROCHLORIDE, 96
- Synonyms
- 1400W2HCl;1400W (hydrochloride);1400 W DIHYDROCHLORIDE, 96;1400W - CAS 214358-33-5 - Calbiochem;N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride;N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride;inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
- CBNumber
- CB5502105
- Molecular Formula
- C8H11NO
- Formula Weight
- 137.17904
- MOL File
- 214358-33-5.mol
1400 W DIHYDROCHLORIDE, 96 Property
- Melting point:
- 208 °C
- storage temp.
- -20°C
- solubility
- Soluble in Water (up to 25 mg/ml).
- form
- White solid
- color
- White
- Water Solubility
- Soluble to 100 mM in water
- Stability:
- Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day.
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29242998
N-Bromosuccinimide Price
- Product number
- W4262
- Product name
- 1400W dihydrochloride
- Purity
- >98%, solid
- Packaging
- 10mg
- Price
- $167
- Updated
- 2024/03/01
- Product number
- 100050
- Product name
- 1400W
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 81520
- Product name
- 1400W (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- 81520
- Product name
- 1400W (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 81520
- Product name
- 1400W (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $410
- Updated
- 2024/03/01
1400 W DIHYDROCHLORIDE, 96 Chemical Properties,Usage,Production
Description
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2
Chemical Properties
white to off-white powder
Uses
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.
Uses
1400W dihydrochloride has been used:
- as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
- as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
- to study its efficacy on renal ischemia/ reperfusion injury in rats
- as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation
General Description
A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
References/Citations 1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959 2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300 3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255
1400 W DIHYDROCHLORIDE, 96 Preparation Products And Raw materials
Raw materials
Preparation Products
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