4-PHENYLCINNAMIC ACID Chemical Properties

Melting point:

224-225°C

Boiling point:

412.9±24.0 °C(Predicted)

Density 

1.178±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder

pka

4.46±0.10(Predicted)

color 

White

Water Solubility 

Slightly soluble in water.

BRN 

1955124

CAS DataBase Reference

13026-23-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N,Xn

Risk Statements 

22-51/53

Safety Statements 

22-24/25-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2916399090

MSDS

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4-PHENYLCINNAMIC ACID Usage And Synthesis

Uses

4-Phenylcinnamic acid is used as pharmaceutical intermediates and for chemical research.

Synthesis

General method: p-phenylbenzaldehyde (0.1 mol) and glacial acetic acid (0.1 mol) were dissolved in dichloromethane (15 mL) under nitrogen protection, followed by the addition of titanium tetrachloride (TiCl4, 0.21 mol). The reaction mixture was stirred at room temperature for 20 min. Subsequently, triethylamine (Et3N, 0.25 mol) was slowly added dropwise over 10 minutes, and the reaction continued to be stirred at room temperature for 3-4 hours after the drop was completed. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the organic layer was separated by adding water (25 mL) to dilute the reaction mixture. The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford (E)-4-phenylcinnamic acid (1) in high purity and yield.

References

[1] Tetrahedron Letters, 2014, vol. 55, # 24, p. 3503 - 3506

4-PHENYLCINNAMIC ACID(13026-23-8)Related Product Information

• 4-PHENYLCINNAMIC ACID
• alpha-Phenylcinnamic acid
• CIS-2-PHENYLCINNAMIC ACID,cis-α-Phenylcinnamic acid
• Octocrylene
• 4-[1,1'-BIPHENYL]-4-YL-2-OXO-2,5-DIHYDRO-3-FURANCARBONITRILE
• α-Cyano-4-phenylcinnamic acid
• Α-PHENYLCINNAMIC ACID
• RARECHEM AL BK 1242
• RARECHEM AL BK 1363
• RARECHEM AL BI 1098
• RARECHEM AL BK 1341
• RARECHEM AL BK 1367
• RARECHEM AL BK 1337
• RARECHEM AL BK 1217
• RARECHEM AL BK 1342
• RARECHEM AL BK 1240
• RARECHEM AL BK 1218
• Bismuth 3-(4-biphenylyl)acrylate