2-METHYL-6-NITROBENZOIC ANHYDRIDE Chemical Properties

Melting point:

173-177 °C

Boiling point:

559.4±50.0 °C(Predicted)

Density 

1.416±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

very faint turbidity in hot Toluene

form 

powder to crystal

color 

White to Yellow to Orange

InChI

InChI=1S/C16H12N2O7/c1-9-5-3-7-11(17(21)22)13(9)15(19)25-16(20)14-10(2)6-4-8-12(14)18(23)24/h3-8H,1-2H3

InChIKey

YEKPNMQQSPHKBP-UHFFFAOYSA-N

SMILES

C(C1C(=CC=CC=1N(=O)=O)C)(=O)OC(C1C(=CC=CC=1N(=O)=O)C)=O

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29163990

2-METHYL-6-NITROBENZOIC ANHYDRIDE Usage And Synthesis

Uses

2-Methyl-6-nitrobenzoic anhydride can be used:

• As a versatile lactonization reagent applicable in the preparation of varieties of macrolide natural products and lactones.
• As a reaction promoter in the synthesis of carboxamide derivatives by using corresponding amines and carboxylic acids.
• In the total synthesis of GRP78 inhibitor prunustatin A, antifungal compound (3R,16E,20E,23R)-(?)-eushearilide and an antiobestic drug tetrahydrolipstatin.

General Description

2-Methyl-6-nitrobenzoic anhydride is a reagent employed as a coupling promoter in the synthesis of amides, lactones, esters, and peptides.

2-METHYL-6-NITROBENZOIC ANHYDRIDE(434935-69-0)Related Product Information

• 2-METHYL-6-NITROBENZOIC ACID
• Benzoic anhydride
• METHYL-2METHYL-6-NITRO-BENZOATE
• 2-METHYL-6-NITROBENZOIC ANHYDRIDE
• 3-Methyl-4-nitrobenzoic acid
• Methyl 5-bromo-2-hydroxy-3-nitrobenzenecarboxylate
• 3-Methyl-2-nitrobenzoic acid
• 4-Nitrobenzoic acid