(3-AMINO-PYRIDIN-4-YL)-METHANOL Chemical Properties

Melting point:

118.7-118.9°C

Boiling point:

366.6±27.0 °C(Predicted)

Density 

1.257±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

13.31±0.10(Predicted)

Appearance

White to yellow Solid

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29333990

(3-AMINO-PYRIDIN-4-YL)-METHANOL Usage And Synthesis

Chemical Properties

White solid

Synthesis

Step 2: Three aliquots were carefully added to an anhydrous THF (200 mL) slurry of solid compound 3-aminoisonicotinic acid (9.5 g, 69 mmol) to LiAlH4 (9.5 g, 250 mmol). The resulting reaction mixture was stirred at room temperature for 2 days. Upon completion of the reaction, it was cooled in an ice bath and water (10 mL), 15% NaOH aqueous solution (10 mL) and water (30 mL) were added sequentially dropwise to quench the reaction. The reaction mixture was filtered through a diatomaceous earth pad and washed several times with THF. After evaporation of the solvent, the resulting oil solidified on standing. The reaction mixture was purified using silica gel fast chromatography with 5% CH3OH (containing NH3)/EtOAc as eluent to afford the target product 3-amino-4-hydroxymethylpyridine 6.21 g (72% yield).LC-MS: m/z = 125 ([M+H]+).

References

[1] Patent: WO2004/831, 2003, A1. Location in patent: Page 22
[2] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 95
[3] Australian Journal of Chemistry, 1993, vol. 46, # 7, p. 987 - 993
[4] Patent: WO2011/38572, 2011, A1. Location in patent: Page/Page column 71; 72

(3-AMINO-PYRIDIN-4-YL)-METHANOL(152398-05-5)Related Product Information

• (2-AMINO-PYRIDIN-4-YL)-METHANOL
• (3-AMINO-PYRIDIN-2-YL)-METHANOL
• (6-AMINO-PYRIDIN-3-YL)-METHANOL
• 4-(AMINOPYRIDINE-3-YL) METHANOL (2-AMINO-PYRIDIN-3-YL)-METHANOL,(2-Amino-pyridin-3-yl)-methanol ,97%,(2-AMINO-PYRIDIN-3-YL)-METHANOL
• (4-AMINO-PYRIDIN-3-YL)-METHANOL