DEXLOXIGLUMIDE
DEXLOXIGLUMIDE Basic information
- Product Name:
- DEXLOXIGLUMIDE
- Synonyms:
-
- DEXLOXIGLUMIDE
- (R)-4-(3,4-DichlorobenzaMido)-5-((3-Methoxypropyl)(pentyl)aMino)-5-oxopentanoic acid
- pentanoic acid, 4-[(3,4-dichlorobenzoyl)amino]-5-[(3-methoxypropyl)pentylamino]-5-oxo-, (4r)-
- -4-(3,4-Dichlorobenzamido)
- -5-((3-methoxypropyl)
- (R)-4-(3,4-Dichlorobenzoylamino)-5-[(3-methoxypropyl)pentylamino]-5-oxopentanoic acid
- (4R)-4-[[(3,4-dichlorophenyl)-oxomethyl]amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
- (4r)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic Acid
- CAS:
- 119817-90-2
- MF:
- C21H30Cl2N2O5
- MW:
- 461.38
- Mol File:
- 119817-90-2.mol
DEXLOXIGLUMIDE Chemical Properties
- Boiling point:
- 632.2±55.0 °C(Predicted)
- Density
- 1.233±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 50 mg/ml, sonicated
- form
- A solid
- pka
- 4.48(at 25℃)
- color
- White to off-white
Safety Information
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-37/39
DEXLOXIGLUMIDE Usage And Synthesis
Uses
Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].
Definition
ChEBI: Dexloxiglumide is a glutamic acid derivative.
References
[1] Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9. DOI:10.1111/j.0953-0673.1996.00411.x
[2] Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6. PMID:16484960
DEXLOXIGLUMIDESupplier
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