D-Methionine Chemical Properties

Melting point:

273-275 °C

alpha 

-24 º (c=8, 6N HCl)

Boiling point:

306.9±37.0 °C(Predicted)

Density 

1.113 (estimate)

refractive index 

1.5216 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

53 g/L (20°C)

pka

2.23±0.10(Predicted)

form 

Powder

color 

White to off-white

Water Solubility 

53 g/L (20 ºC)

Merck 

14,5975

BRN 

1722293

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

0.370 (est)

CAS DataBase Reference

348-67-4(CAS DataBase Reference)

NIST Chemistry Reference

D-(l)-Methionine(348-67-4)

EPA Substance Registry System

D-Methionine (348-67-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

33-36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

RTECS 

PD0455000

TSCA 

Yes

HS Code 

29304090

MSDS

• Language:English Provider:(R)-2-Amino-4-(methylmercapto)butyric acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

D-Methionine Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

D-Methionine is used to rescue noise-induced hearing loss. It is used to improve the nutritive value of animal feed.

Definition

ChEBI: An optically active form of methionine having D-configuration.

Biochem/physiol Actions

D-methionine has been shown to rescue noise-induced hearing loss.

Synthesis

The general procedure for the determination of N-d-AAase activity using N-acetyl-D-methionine as substrate was as follows: first, N-d-AAase was incubated with N-acetyl-D-methionine at 4°C. Subsequently, a colorimetric solution mixture containing d-amino acid oxidase (coupled with horseradish peroxidase), peroxidase (10 U/mL), 4-aminoantipyrine (0.04 mg/mL) and phenol (0.8 mM) was added. Absorbance (OD) was measured at 520 nm. The unit of enzyme activity was defined as the amount of catalytic production of 1 μmol D-methionine per minute. Protein concentration was determined by the Bradford method using bovine serum albumin as standard [32]. The kinetic parameters kcat and Km were determined by fitting the initial rate as a function of substrate concentration to the Michaelis-Menten equation.

References

[1] Journal of the American Chemical Society, 1953, vol. 75, p. 4058
[2] Journal of Biological Chemistry, 1952, vol. 194, p. 455,458
[3] Journal of the American Chemical Society, 1951, vol. 73, p. 4604
[4] Bulletin of the Agricultural Chemical Society of Japan, 1957, vol. 21, p. 235,237
[5] Bioscience, biotechnology, and biochemistry, 1992, vol. 56, # 9, p. 1392 - 1395

D-Methionine(348-67-4)Related Product Information

• 4-Aminobutyric acid
• L-Methionine
• Zinc methionine sulfate
• ISOMETHIOZIN
• Molasses
• 6-Aminocaproic acid
• Butyric Acid
• Glycine
• S-ADENOSYL-L-METHIONINE
• DL-Methionine
• D-(-)-Asparagine monohydrate
• D(-)-Glutamic acid
• D-2-Amino-4-methylpentanoic acid
• BOC-D-Methionine
• D-ETHIONINE
• N-Cbz-L-methionine
• Ammonia
• H-D-MET-OME HCL