CHLOROMETHYL PHENYL SULFIDE Chemical Properties

Boiling point:

66 °C/0.2 mmHg (lit.)

Density 

1.184 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.594(lit.)

Flash point:

214 °F

storage temp. 

2-8°C

solubility 

sol most organic solvents; insol H2O

form 

Liquid

color 

Clear colorless to pale yellow

Sensitive 

Stench

BRN 

1617369

InChIKey

LLSMWLJPWFSMCP-UHFFFAOYSA-N

CAS DataBase Reference

7205-91-6(CAS DataBase Reference)

Safety Information

Safety Statements 

23-24/25

RIDADR 

UN 3334

WGK Germany 

3

F 

10-13

Hazard Note 

Stench

HazardClass 

4.1

PackingGroup 

III

HS Code 

29309099

MSDS

• Language:English Provider:SigmaAldrich

CHLOROMETHYL PHENYL SULFIDE Usage And Synthesis

Uses

Reagent for the high-yield thiomethylation of O-silylated lactone and ester enolates in the synthesis of α-methylene lactones and esters.1

Uses

Reagent for the high-yield thiomethylation of O-silylated lactone and ester enolates in the synthesis of α-methylene lactones and esters.

Synthesis

The two most convenient methods of chloromethyl phenyl sulfide are the reaction of Thioanisole with Sulfuryl Chloride and the reaction of Thiophenol with bromochloromethane using 1,8-Diazabicyclo[5.4.0]undec-7-ene or an alkali metal hydroxide as the base.

storage

Chloromethyl phenyl sulfideshould be handled in a well-ventilated fume hood and kept cooled. Freshly prepared material can be stored at 0-5 °C without any appreciable decomposition. It is advisable to use freshly prepared or distilled material for reactions.

Purification Methods

Dissolve the sulfide in CH2Cl2 or CCl4 and dry it (CaCl2), or pass it through a tube of CaCl2 and distil it using a fractionating column. Harmful vapours. It gives the sulfone [7205-98-3] (b 130o/1mm and m 53o from EtOH) [Beilstein 6 IV 1507] on oxidation with permonophthalic acid. [B.hme et al. Justus Liebigs Ann Chem 563 54 64 1949.] [Beilstein 6 III 1002.]

CHLOROMETHYL PHENYL SULFIDE(7205-91-6)Related Product Information

• Chlorosulfonyl isocyanate
• CHLOROMETHYL PHENYL SULFOXIDE
• CHLOROMETHYL 4-CHLOROPHENYL SULFIDE
• CHLOROMETHYL P-TOLYL SULFIDE
• PHENYL CHLOROTHIOFORMATE
• CHLOROMETHYL PHENYL SULFONE
• CHLOROMETHYL PHENYL SULFIDE
• Chloromethane
• P-CHLOROPHENYL TRICHLOROMETHYL SULFIDE
• 3-(3-chloro-4-(chlorodifluoromethyl)thiophenyl)-1,1-dimethylurea
• PHENYL CHLORODITHIOFORMATE
• 2-CHLORO-BENZO[E][1,3]THIAZIN-4-ONE
• 1-chloro-4-[(chloromethyl)sulphonyl]benzene
• 1-[(CHLOROMETHYL)SULFONYL]NAPHTHALENE
• P-TOLUENESULFONYLMETHYL CHLORIDE
• 1-BENZYL-3-CHLORO-3-[(4-CHLOROPHENYL)SULFANYL]DIHYDRO-1H-PYRROLE-2,5-DIONE
• 3,5-BIS(TRIFLUOROMETHYL)PHENYL CHLOROMETHYL SULFONE
• Thiazolo[4,5-h]isoquinoline, 2-chloro- (9CI)