Semorinemab
Semorinemab Basic information
- Product Name:
- Semorinemab
- Synonyms:
-
- Semorinemab
- Research Grade Semorinemab(DHC82404)
- Research Grade Semorinemab
- Semorinemab (anti-Tau)
- CAS:
- 2159141-27-0
- MW:
- 0
- Mol File:
- Mol File
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Semorinemab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Semorinemab Usage And Synthesis
Uses
Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1].
in vivo
Semorinemab (3, 10 and 30 mg/kg; i.p., once weekly for 13 weeks) reduces accumulation of Tau pathology in a transgenic (Tg) mouse model of tauopathy[1].
| Animal Model: | Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) [1] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks |
| Result: | Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205. |
References
[1] Ayalon G, et al. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Sci Transl Med. 2021 May 12;13(593):eabb2639. DOI:10.1126/scitranslmed.abb2639
SemorinemabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
- 422450190@qq.com
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