Tigatuzumab
Tigatuzumab Basic information
- Product Name:
- Tigatuzumab
- Synonyms:
-
- Tigatuzumab
- Research Grade Tigatuzumab (DHA29102)
- Research Grade Tigatuzumab
- Tigatuzumab (anti-TNFRSF10B)
- CAS:
- 918127-53-4
- MW:
- 0
- Mol File:
- Mol File
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Tigatuzumab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Tigatuzumab Usage And Synthesis
Uses
Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer[1].
in vivo
Tigatuzumab (3 mg/kg; i.v. weekly for 4 weeks) effectively represses the tumor growth in human pancreatic cancer MIA PaCa-2-RFP orthotopic mouse model[1].
| Animal Model: | Nude mice with MIA PaCa-2-RFP human pancreatic cancer cells injection[1] |
| Dosage: | 3 mg/kg |
| Administration: | Intravenous injection; 3 mg/kg weekly for 4 weeks |
| Result: | Reduced the tumor volume and decreased the density of viable cancer cells in tumors. |
References
[1] Yamamoto J, et al. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 Nov 1;492:174-184. DOI:10.1016/j.canlet.2020.07.034
TigatuzumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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ShangHai Biochempartner Co.,Ltd
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Guangzhou Hongyuan Chemical Co.,Ltd
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Wuhan Chemstan Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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