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Heptafluorobutyric acid

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Heptafluorobutyric acid Basic information

Product Name:
Heptafluorobutyric acid
Synonyms:
  • heptafluorobutanoicacid
  • TIMTEC-BB SBB008777
  • N-HEPTAFLUOROBUTYRIC ACID
  • PERFLUOROBUTYRIC ACID
  • PERFLUOROBUTBUTYRIC ACID
  • RARECHEM AL BO 0423
  • HEPTAFLUOROBUTYRC ACID
  • HEPTAFLUOROBUTYRIC ACID, FOR ION CHROMATOGRAPHY
CAS:
375-22-4
MF:
C4HF7O2
MW:
214.04
EINECS:
206-786-3
Product Categories:
  • HPLC and LCMS Mobile Phase Additive
  • GC Derivatizing Reagents
  • Analytical Chemistry
  • Ion-Pair Reagents for HPLC
  • LC/MS Ion-Pair Reagents for Basic Samples
  • Acylation (GC Derivatizing Reagents)
  • Pharmaceutical Intermediates
Mol File:
375-22-4.mol
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Heptafluorobutyric acid Chemical Properties

Melting point:
-17.5 °C
Boiling point:
120 °C755 mm Hg(lit.)
Density 
1.645 g/mL at 25 °C(lit.)
vapor density 
7 (vs air)
vapor pressure 
~10 mm Hg ( 25 °C)
refractive index 
n20/D 1.3(lit.)
Flash point:
120-121°C
storage temp. 
Store below +30°C.
solubility 
Chloroform: soluble; Methanol: soluble
form 
Powder
pka
pK1:0.17 (25°C)
Specific Gravity
approximate 1.6
color 
Clear colorless to faint yellow
PH
1 (H2O, 20℃)
Water Solubility 
miscible
Sensitive 
Light Sensitive
BRN 
1426882
InChIKey
YPJUNDFVDDCYIH-UHFFFAOYSA-N
CAS DataBase Reference
375-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Butanoic acid, heptafluoro-(375-22-4)
EPA Substance Registry System
Heptafluorobutyric acid (375-22-4)
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Safety Information

Hazard Codes 
C
Risk Statements 
34-35
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
ET4025000
3-8-10
Hazard Note 
Corrosive
TSCA 
T
HazardClass 
8
PackingGroup 
II
HS Code 
29159000

MSDS

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Heptafluorobutyric acid Usage And Synthesis

Chemical Properties

Clear colorless to faintly yellow liquid

Uses

Heptafluorobutyric acid is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides. It is used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It is an effective additive for zinc electrodeposition.

Uses

Perfluorobutyric acid was used as mobile phase modifier for enhancement of selectivity in the HPLC analysis of histone proteins. It was used as ion pairing reagent in preparative and analytical reserved phase HPLC of underivatised peptides.

Uses

Heptafluorobutyric acid (HBFA) has been used widely for purifying neuropeptides because of its excellent resolution. The use of heptafluorobutyric acid as a volatile ion-pair reagent in the high-performance liquid chromatographic isolation of SB-223070 John K.
Heptafluorobutyric acid is a strong acid and ion-pairing agent that is used in analytical chemistry, notably in HPLC and in gas chromatography/mass spectrometry (GC/MS), in a similar manner to trifluoroacetic acid (TFA). The strong acidity of HFBA ensures that other acidic groups such as carboxylic acid moieties on biomolecules remain protonated, and thus the biomolecule samples are able to interact with organic solvents in such processes as reverse phase chromatography. The longer alkyl chain of HFBA makes it more hydrophobic than TFA, and thus HFBA can be utilized with more hydrophobic samples.
HFBA (0.1%) has been used in the mobile phase of an HPLC/LC-MS protocol for the detection of marine bacterioplankton sideophores.A study of the effects of various acids, including HFBA, on the resolution of intact proteins by reversed-phase LC/ESI-MS has been published.A modified version of the peptide ladder sequencing technique that incorporates allyl isothiocyanate and HFBA has been reported.

Definition

ChEBI: A monocarboxylic acid that is perfluorinated butyric acid.

General Description

Perfluorobutyric acid is an effective additive for zinc electrodeposition.

Hazard

Irritant to tissue.

Purification Methods

Fractionally distil the acid twice in an Oldershaw column (p 10) with an automatic vapour-dividing head, the first distillation being in the presence of conc H2SO4 as a drying agent. (Take care with the hot acid.) [Beilstein 2 IV 810.]

Heptafluorobutyric acid Preparation Products And Raw materials

Preparation Products

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