Hydroxylamine-O-sulfonic acid CAS#: 2950-43-8

Hydroxylamine-O-sulfonic acid Basic information

Product Name:

Hydroxylamine-O-sulfonic acid

Synonyms:

amidoperoxymonosulfuricacid
amidosulfonicperacid
aminomonopersulfuricacid
haos
o-hydroxylammoniumsulfonate
permonosulfamicacid
sulfoperamidicacid
HOS

CAS:

2950-43-8

MF:

H3NO4S

MW:

113.09

EINECS:

220-971-6

Product Categories:

Building Blocks
Chemical Synthesis
Pharmaceutical Intermediates
Organic Building Blocks
Sulfonic/Sulfinic Acids
Sulfur Compounds
Amination
Hydroxylamines
Hydroxylamines (O-Substituted)
Synthetic Organic Chemistry
Organic Building Blocks
Sulfonic/Sulfinic Acids
Sulfur Compounds
bc0001

Mol File:

2950-43-8.mol

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Hydroxylamine-O-sulfonic acid Chemical Properties

Melting point:: 210 °C (dec.)(lit.)
Boiling point:: 39 °C(Press: 0.4 Torr)
Density: 2.2 g/cm3 (20℃)
vapor pressure: 0-53.329Pa at 25-39℃
storage temp.: 2-8°C
solubility: 675g/l (slow decomposition)
pka: -6.47±0.18(Predicted)
form: Crystalline Powder
color: White
PH: 0.8 (100g/l, H2O, 20℃)
Water Solubility: soluble
Sensitive: Hygroscopic
BRN: 956566
InChIKey: DQPBABKTKYNPMH-UHFFFAOYSA-N
CAS DataBase Reference: 2950-43-8(CAS DataBase Reference)
EPA Substance Registry System: Hydroxylamine-O-sulfonic acid (2950-43-8)

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Safety Information

Hazard Codes: C,N
Risk Statements: 34-50-43-40-22
Safety Statements: 26-36/37/39-45-61-28A-27-22
RIDADR: UN 3260 8/PG 3
WGK Germany: 3
RTECS: NC5427000
F: 10-21
Hazard Note: Irritant
TSCA: Y
HazardClass: 8
PackingGroup: III
HS Code: 28111980

MSDS

Language:English Provider:HOSA
Language:English Provider:SigmaAldrich
Language:English Provider:ACROS
Language:English Provider:ALFA

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Hydroxylamine-O-sulfonic acid Usage And Synthesis

Chemical Properties

white to slightly beige crystalline powder

Uses

Hydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion.

Uses

Hydroxylamine-O-sulfonic acid (HOSA) may be used to synthesize (Z)-1H-purin-6(7H)-ylideneaminooxysulfonic acid.
HOSA may be used as an aminating reagent in the synthesis of:

1-aminotetrazoles and 2-aminotetrazoles
N-aminopiperidine (NAPP)
1H,1′ H-2,2′-biimidazole-1,1′-diamine

General Description

Hydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H₂SO₄.

Purification Methods

Stir the solid vigorously with anhydrous Et2O and filter it off using large volumes of dry Et2O. Drain dry at the pump for 5minutes and then for 12-14hours in a vacuum. Store it in a vacuum desiccator over conc H2SO4. Determine the purity by oxidation of iodide to I2. It must be stored in a dry atmosphere at 0-4o. It decomposes slowly in H2O at 25o and more rapidly above this temperature. [Matsuguma & Andrieth Inorg Synth V 122 1957.]

Hydroxylamine-O-sulfonic acid Preparation Products And Raw materials

Preparation Products

1-ISOPROPYL-5-HYDROXYPYRAZOL Dimethylglyoxime Pyrazolo[1,5-a]pyridine-3-carboxylic acid 3-(3-Nitrophenyl)propionic acid

Hydroxylamine-O-sulfonic acidSupplier

Shanghai Pansopharm Technology Co., Ltd. Gold

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Shandong Winner Biotechnology Co., Ltd. Gold

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