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Hydroxylamine-O-sulfonic acid

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Hydroxylamine-O-sulfonic acid Basic information

Product Name:
Hydroxylamine-O-sulfonic acid
Synonyms:
  • amidoperoxymonosulfuricacid
  • amidosulfonicperacid
  • aminomonopersulfuricacid
  • haos
  • o-hydroxylammoniumsulfonate
  • permonosulfamicacid
  • sulfoperamidicacid
  • HOS
CAS:
2950-43-8
MF:
H3NO4S
MW:
113.09
EINECS:
220-971-6
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Pharmaceutical Intermediates
  • Organic Building Blocks
  • Sulfonic/Sulfinic Acids
  • Sulfur Compounds
  • Amination
  • Hydroxylamines
  • Hydroxylamines (O-Substituted)
  • Synthetic Organic Chemistry
  • Organic Building Blocks
  • Sulfonic/Sulfinic Acids
  • Sulfur Compounds
  • bc0001
Mol File:
2950-43-8.mol
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Hydroxylamine-O-sulfonic acid Chemical Properties

Melting point:
210 °C (dec.)(lit.)
Boiling point:
39 °C(Press: 0.4 Torr)
Density 
2.2 g/cm3 (20℃)
vapor pressure 
0-53.329Pa at 25-39℃
storage temp. 
2-8°C
solubility 
675g/l (slow decomposition)
pka
-6.47±0.18(Predicted)
form 
Crystalline Powder
color 
White
PH
0.8 (100g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
956566
InChIKey
DQPBABKTKYNPMH-UHFFFAOYSA-N
CAS DataBase Reference
2950-43-8(CAS DataBase Reference)
EPA Substance Registry System
Hydroxylamine-O-sulfonic acid (2950-43-8)
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Safety Information

Hazard Codes 
C,N
Risk Statements 
34-50-43-40-22
Safety Statements 
26-36/37/39-45-61-28A-27-22
RIDADR 
UN 3260 8/PG 3
WGK Germany 
3
RTECS 
NC5427000
10-21
Hazard Note 
Irritant
TSCA 
Y
HazardClass 
8
PackingGroup 
III
HS Code 
28111980

MSDS

  • Language:English Provider:HOSA
  • Language:English Provider:SigmaAldrich
  • Language:English Provider:ACROS
  • Language:English Provider:ALFA
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Hydroxylamine-O-sulfonic acid Usage And Synthesis

Chemical Properties

white to slightly beige crystalline powder

Uses

Hydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion.

Uses

Hydroxylamine-O-sulfonic acid (HOSA) may be used to synthesize (Z)-1H-purin-6(7H)-ylideneaminooxysulfonic acid.
HOSA may be used as an aminating reagent in the synthesis of:

  • 1-aminotetrazoles and 2-aminotetrazoles
  • N-aminopiperidine (NAPP)
  • 1H,1′ H-2,2′-biimidazole-1,1′-diamine

General Description

Hydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.

Purification Methods

Stir the solid vigorously with anhydrous Et2O and filter it off using large volumes of dry Et2O. Drain dry at the pump for 5minutes and then for 12-14hours in a vacuum. Store it in a vacuum desiccator over conc H2SO4. Determine the purity by oxidation of iodide to I2. It must be stored in a dry atmosphere at 0-4o. It decomposes slowly in H2O at 25o and more rapidly above this temperature. [Matsuguma & Andrieth Inorg Synth V 122 1957.]

Hydroxylamine-O-sulfonic acid Preparation Products And Raw materials

Preparation Products

Hydroxylamine-O-sulfonic acidSupplier

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