Hydroxylamine-O-sulfonic acid
Hydroxylamine-O-sulfonic acid Basic information
- Product Name:
- Hydroxylamine-O-sulfonic acid
- Synonyms:
-
- amidoperoxymonosulfuricacid
- amidosulfonicperacid
- aminomonopersulfuricacid
- haos
- o-hydroxylammoniumsulfonate
- permonosulfamicacid
- sulfoperamidicacid
- HOS
- CAS:
- 2950-43-8
- MF:
- H3NO4S
- MW:
- 113.09
- EINECS:
- 220-971-6
- Product Categories:
-
- Building Blocks
- Chemical Synthesis
- Pharmaceutical Intermediates
- Organic Building Blocks
- Sulfonic/Sulfinic Acids
- Sulfur Compounds
- Amination
- Hydroxylamines
- Hydroxylamines (O-Substituted)
- Synthetic Organic Chemistry
- Organic Building Blocks
- Sulfonic/Sulfinic Acids
- Sulfur Compounds
- bc0001
- Mol File:
- 2950-43-8.mol
Hydroxylamine-O-sulfonic acid Chemical Properties
- Melting point:
- 210 °C (dec.)(lit.)
- Boiling point:
- 39 °C(Press: 0.4 Torr)
- Density
- 2.2 g/cm3 (20℃)
- vapor pressure
- 0-53.329Pa at 25-39℃
- storage temp.
- 2-8°C
- solubility
- 675g/l (slow decomposition)
- pka
- -6.47±0.18(Predicted)
- form
- Crystalline Powder
- color
- White
- PH
- 0.8 (100g/l, H2O, 20℃)
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 956566
- InChIKey
- DQPBABKTKYNPMH-UHFFFAOYSA-N
- CAS DataBase Reference
- 2950-43-8(CAS DataBase Reference)
- EPA Substance Registry System
- Hydroxylamine-O-sulfonic acid (2950-43-8)
Safety Information
- Hazard Codes
- C,N
- Risk Statements
- 34-50-43-40-22
- Safety Statements
- 26-36/37/39-45-61-28A-27-22
- RIDADR
- UN 3260 8/PG 3
- WGK Germany
- 3
- RTECS
- NC5427000
- F
- 10-21
- Hazard Note
- Irritant
- TSCA
- Y
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 28111980
MSDS
- Language:English Provider:HOSA
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
Hydroxylamine-O-sulfonic acid Usage And Synthesis
Chemical Properties
white to slightly beige crystalline powder
Uses
Hydroxylamine-O-sulfonic acid is used in the synthesis of quinolones for the benzodiazepine site of GABAA receptors. It is also used as a polymerization catalyst and an amination reagent. It is involved in the preparation of diazene by reacting with an alkali. It is also used in the inhibition of polychlorinated dibenzo-p-dioxins (PCDD) as well as (polychlorinated biphenyl) PCB formation in co-combustion.
Uses
Hydroxylamine-O-sulfonic acid (HOSA) may be used to synthesize (Z)-1H-purin-6(7H)-ylideneaminooxysulfonic acid.
HOSA may be used as an aminating reagent in the synthesis of:
- 1-aminotetrazoles and 2-aminotetrazoles
- N-aminopiperidine (NAPP)
- 1H,1′ H-2,2′-biimidazole-1,1′-diamine
General Description
Hydroxylamine-O-sulfonic acid is a versatile synthetic reagent. It is widely employed as a nucleophile and as an electrophile in various organic syntheses. It can be synthesized by reacting hydroxylamine sulfate with 30% fuming H2SO4.
Purification Methods
Stir the solid vigorously with anhydrous Et2O and filter it off using large volumes of dry Et2O. Drain dry at the pump for 5minutes and then for 12-14hours in a vacuum. Store it in a vacuum desiccator over conc H2SO4. Determine the purity by oxidation of iodide to I2. It must be stored in a dry atmosphere at 0-4o. It decomposes slowly in H2O at 25o and more rapidly above this temperature. [Matsuguma & Andrieth Inorg Synth V 122 1957.]
Hydroxylamine-O-sulfonic acid Preparation Products And Raw materials
Preparation Products
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Hydroxylamine-O-sulfonic acid(2950-43-8)Related Product Information
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- Glycine
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- METARAMINOL
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- HYDROXYLAMINE
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- HYDROXYLAMINE NITRATE
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