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tert-butyl 5-oxo-L-prolinate

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tert-butyl 5-oxo-L-prolinate Basic information

Product Name:
tert-butyl 5-oxo-L-prolinate
Synonyms:
  • L-PyroglutaMic acid ter-butyl ester
  • L-Pyr-Otbu
  • L-Proline,5-oxo-, 1,1-diMethylethyl ester
  • tert-butyl (2S)-5-oxopyrrolidine-2-carboxylate
  • tert-Butyl L-PyroglutaMate
  • (S)-tert-Butyl 5-oxopyrrolidine-2-carboxylate
  • 2-Methyl-2-propanyl 5-oxo-L-prolinate
  • tert-Butyl (S)-5-oxo-2-pyrrolidinecarboxylate
CAS:
35418-16-7
MF:
C9H15NO3
MW:
185.22
EINECS:
252-555-5
Mol File:
35418-16-7.mol
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tert-butyl 5-oxo-L-prolinate Chemical Properties

Melting point:
102.0 to 108.0 °C
Boiling point:
319.2±35.0 °C(Predicted)
Density 
1.099±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
14.65±0.40(Predicted)
form 
Powder
color 
White
BRN 
3590226
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29339900
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tert-butyl 5-oxo-L-prolinate Usage And Synthesis

Uses

tert-Butyl (S)-2-pyrrolidone-5-carboxylate can be used:

  • As a starting material/synthon in the synthesis of angiotensin-converting enzyme inhibitors.
  • In the synthesis of phenanthroindolizidine alkaloids named (+)-tylophorine and antofine.
  • As a starting material in the synthesis of radioligands [18F]IUR-1602 and [18F]IUR-1601, applicable for imaging of P2X7R, a therapeutic target for neuroinflammation.

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