4-(N-Methyl-N-benzylamino)piperidine Chemical Properties

Boiling point:

118-120 °C(Press: 0.1 Torr)

Density 

1.01±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

10.11±0.10(Predicted)

Safety Information

RIDADR 

UN2735

HazardClass 

IRRITANT

4-(N-Methyl-N-benzylamino)piperidine Usage And Synthesis

Application

4-(N-methyl-N-benzyl)aminopiperidine can be used as a pharmaceutical synthesis intermediate. If 4-bromoquinoline-6-carboxylic acid is inhaled, move the patient to fresh air.

Synthesis

4-(N-methyl-N-benzyl)aminopiperidine was prepared as follows: to a mixed solution of 1,4-dioxane/methanol (1/1, 8.0 mL) of 4-(N-benzyl-N-methylamino)piperidine-1-carboxylic acid tert-butyl ester (1.00 g, 3.28 mmol) was added to a 1,4-dioxane solution of hydrogen chloride (4.0 N, 3.28 mL.) at room temperature, 13.1 mmol) and the reaction solution was stirred at the same temperature for 6 hours. The reaction solution was concentrated under reduced pressure, saturated aqueous sodium bicarbonate solution was added and extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by fast chromatography (silica gel, chloroform/methanol) to afford 4-(N-methyl-N-benzyl)aminopiperidine (0.650 g, 0.318 mmol, 97%) as a colorless oil.

4-(N-Methyl-N-benzylamino)piperidine(76167-62-9)Related Product Information

• Benzyltrimethylammonium hydroxide
• Kresoxim-methyl
• Benzyl chloromethyl ether
• Methyl acrylate
• 1-Aminopiperidine
• Methyl salicylate
• Methanol
• Dimethylbenzylcarbinyl acetate
• METSULFURON METHYL
• Methylparaben
• 2,2,6,6-Tetramethylpiperidinooxy
• Tribenuron methyl
• Basic Violet 1
• 2,2,6,6-Tetramethyl-4-piperidinol
• Methyl
• Phenylacetone
• AZINPHOS-METHYL
• Piperidine hydrochloride